Higuchi Akio, Oshima Takashi, Yoshihara Kazue, Sakamaki Kentaro, Aoyama Toru, Suganuma Nobuyasu, Yamamoto Naoto, Sato Tsutomu, Cho Haruhiko, Shiozawa Manabu, Yoshikawa Takaki, Rino Yasushi, Kunisaki Chikara, Imada Toshio, Masuda Munetaka
Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
Clinical Research Coordinating Center, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, Japan.
Oncol Lett. 2017 Feb;13(2):905-911. doi: 10.3892/ol.2016.5494. Epub 2016 Dec 14.
Overall survival remains unsatisfactory in stage II/III gastric cancer, even after curative surgery and adjuvant chemotherapy. Platelet-derived growth factor receptor-β (-β) is associated with the proliferation of cancer cells. The present study therefore investigated the association of -β gene expression with patient outcome in 134 stage II/III gastric cancer patients who received adjuvant chemotherapy with S-1. Relative -β gene expression was measured in surgical cancer tissue and adjacent normal mucosa specimens by reverse transcription-quantitative polymerase chain reaction. The -β gene expression levels were found to be significantly higher in the cancer tissues compared with the adjacent normal mucosa. A high level of -β gene expression was associated with a significantly poorer 5-year overall survival rate compared with a low level of -β expression. Upon multivariate analysis, -β gene expression was found to be an independent predictor of survival. Overall, the study indicates that -β overexpression in gastric cancer tissues is a useful independent predictor of outcome in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1.
即使经过根治性手术和辅助化疗，II/III期胃癌患者的总生存期仍不尽人意。血小板衍生生长因子受体-β（PDGFR-β）与癌细胞增殖有关。因此，本研究调查了134例接受S-1辅助化疗的II/III期胃癌患者中PDGFR-β基因表达与患者预后的关系。通过逆转录定量聚合酶链反应测量手术切除的癌组织和相邻正常黏膜标本中的相对PDGFR-β基因表达。结果发现，与相邻正常黏膜相比，癌组织中的PDGFR-β基因表达水平显著更高。与低水平的PDGFR-β表达相比，高水平的PDGFR-β基因表达与显著更差的5年总生存率相关。多因素分析显示，PDGFR-β基因表达是生存的独立预测因素。总体而言，该研究表明，胃癌组织中PDGFR-β的过表达是接受S-1辅助化疗的II/III期胃癌患者预后的一个有用的独立预测因素。
