Xu Xinxian, Wen Hong, Hu Yuezheng, Liu Zhongtang, Pan Xiaoyun
Department of Osteopathy, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Biomed Rep. 2017 Feb;6(2):232-236. doi: 10.3892/br.2017.837. Epub 2017 Jan 9.
The aim of the present study was to compare the efficacy of intra-articular magnesium sulphate and a saline placebo for postoperative pain control following total hip arthroplasty (THA). Sixty patients underwent THA and were randomly allocated into two groups to receive intra-articular injections of either 10 ml magnesium sulphate (100 mg/ml; magnesium group, n=30) or 10 ml normal saline solution (control group, n=30). Postoperative analgesia was maintained by intravenous morphine injection. The outcome measurements were visual analogue score (VAS), morphine consumption and Harris hip score (HHS). The two groups were well matched. The outcome of VAS at rest was significantly lower at postoperative hours 6 and 12 in the magnesium group as compared with the control group, although the difference was insignificant preoperatively and at postoperative hours 2, 4, 24 and 48, and days 3, 7 and 14. This indicator during activity was also lower in the magnesium group at postoperative hour 24 than that of the control group, although the difference was insignificant preoperatively and at hour 48, and days 7 and 14. The consumption of morphine (the total quantity) at 0-6, 6-12 and 0-48 h in the magnesium group was significantly lower than in the control group, although no significant differences were observed at 12-24 and 24-48 h between the groups. The improvements of HHS from preoperative to postoperative scores were statistically significant, however, no significant differences were identified between groups. Thus, the findings indicate that intra-articular magnesium sulphate injections provided improved pain control and reduced the need for morphine when compared with a saline placebo following THA.
本研究的目的是比较关节腔内注射硫酸镁和生理盐水安慰剂对全髋关节置换术（THA）后疼痛控制的效果。60例患者接受了THA手术，并随机分为两组，分别接受关节腔内注射10ml硫酸镁（100mg/ml；硫酸镁组，n = 30）或10ml生理盐水溶液（对照组，n = 30）。术后通过静脉注射吗啡维持镇痛。观察指标为视觉模拟评分（VAS）、吗啡用量和Harris髋关节评分（HHS）。两组患者匹配良好。与对照组相比，硫酸镁组术后6小时和12小时静息时的VAS评分显著降低，尽管术前以及术后2小时、4小时、24小时、48小时、3天、7天和14天差异不显著。术后24小时活动时该指标在硫酸镁组也低于对照组，尽管术前、48小时、7天和14天差异不显著。硫酸镁组0 - 6小时、6 - 12小时和0 - 48小时的吗啡用量（总量）显著低于对照组，尽管两组在12 - 24小时和24 - 48小时未观察到显著差异。术前至术后HHS评分的改善具有统计学意义，然而，两组之间未发现显著差异。因此，研究结果表明，与生理盐水安慰剂相比，THA术后关节腔内注射硫酸镁可改善疼痛控制并减少吗啡用量。
