Department of Spin Surgery, The First Hospital of Changsha, NO.311 Yingpan Road, Kaifu District, Changsha City, Hunan, China.
J Orthop Surg Res. 2021 Oct 10;16(1):583. doi: 10.1186/s13018-021-02609-w.
The analgesic efficacy of magnesium sulphate added to bupivacaine for arthroscopy remains controversial. We conduct a systematic review and meta-analysis to explore the efficacy of magnesium sulphate in combination with bupivacaine for arthroscopy.
We searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through July 2020 for randomized controlled trials (RCTs) assessing the effect of magnesium sulphate plus bupivacaine versus bupivacaine for arthroscopy. This meta-analysis is performed using the random-effect model.
Six RCTs were included in the meta-analysis. Overall, compared with bupivacaine for arthroscopy, combination analgesia using magnesium plus bupivacaine was associated with significantly prolonged duration of analgesia (SMD=0.93; 95% CI=0.27 to 1.60; P=0.006) and first time to analgesic requirement (SMD=196.57; 95% CI=13.90 to 379.24; P=0.03), reduced pain scores (SMD=-1.71; 95% CI=-2.96 to -0.46; P=0.007) and analgesic consumption (SMD=-1.04; 95% CI=-1.49 to -0.60; P<0.00001), but showed no remarkable influence on nausea or vomiting (OR=1.54; 95% CI=0.60 to 3.97; P=0.37).
Magnesium sulphate added to bupivacaine may significantly improve the analgesic efficacy for arthroscopy.
硫酸镁联合布比卡因用于关节镜检查的镇痛效果仍存在争议。我们进行了系统评价和荟萃分析，以探讨硫酸镁联合布比卡因用于关节镜检查的疗效。
我们检索了 PubMed、EMbase、Web of Science、EBSCO 和 Cochrane 图书馆数据库，截至 2020 年 7 月，以评估硫酸镁联合布比卡因与布比卡因用于关节镜检查的随机对照试验（RCT）。本荟萃分析采用随机效应模型进行。
共纳入 6 项 RCT 进行荟萃分析。总体而言，与布比卡因用于关节镜检查相比，硫酸镁联合布比卡因联合镇痛与镇痛持续时间显著延长（SMD=0.93；95%CI=0.27 至 1.60；P=0.006）和首次需要镇痛的时间（SMD=196.57；95%CI=13.90 至 379.24；P=0.03），疼痛评分降低（SMD=-1.71；95%CI=-2.96 至-0.46；P=0.007）和镇痛药物消耗（SMD=-1.04；95%CI=-1.49 至-0.60；P<0.00001），但对恶心或呕吐无明显影响（OR=1.54；95%CI=0.60 至 3.97；P=0.37）。
硫酸镁联合布比卡因可显著提高关节镜检查的镇痛效果。
