Sumi Takuya, Oguri Mitsutoshi, Fujimaki Tetsuo, Horibe Hideki, Kato Kimihiko, Matsui Kota, Takeuchi Ichiro, Murohara Toyoaki, Yamada Yoshiji
Department of Cardiology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi 466-8560, Japan.
Department of Cardiology, Kasugai Municipal Hospital, Kasugai, Aichi 486-8510, Japan.
Biomed Rep. 2017 Feb;6(2):242-250. doi: 10.3892/br.2016.831. Epub 2016 Dec 23.
The aim of the present study was to examine the association of renal function with clinical parameters and conditions in the general population. Study subjects comprised 6,027 community-dwelling individuals who were recruited to the Inabe Health and Longevity Study: A longitudinal genetic epidemiological study of atherosclerotic, cardiovascular and metabolic diseases. The cutoff value, which was used to divide the subjects into those with normal and those with low estimated glomerular filtration rate (eGFR), was 60 ml/min/1.73 m. Bonferroni's correction was applied to establish the statistical significance of the association. Longitudinal analysis using the generalized linear mixed-effect model, following adjustments for age and gender, revealed that the eGFR was significantly associated (P<0.0017) with serum levels of triglycerides, low-density lipoprotein cholesterol, uric acid, blood glycosylated hemoglobin content, fasting plasma glucose and body mass index. These parameters decreased curvilinearly with increases in eGFR. Furthermore, eGFR correlated positively with serum levels of high-density lipoprotein (HDL) cholesterol. Longitudinal analysis using the generalized estimating equation following adjustment for age and gender indicated a significant association (P<0.0024) between eGFR and prevalence of hypertension, type 2 diabetes mellitus, hypo-HDL cholesterolemia, hyperuricemia and obesity. Thus, low eGFR results in detrimental effects on various clinical parameters and conditions, resulting in increased risk of hypertension, dyslipidemia, type 2 diabetes mellitus, hyperuricemia and obesity.
本研究的目的是检验普通人群中肾功能与临床参数及状况之间的关联。研究对象包括6027名社区居民，他们被纳入稻生健康与长寿研究：一项关于动脉粥样硬化、心血管和代谢疾病的纵向遗传流行病学研究。用于将受试者分为估计肾小球滤过率（eGFR）正常和低eGFR两组的临界值为60 ml/min/1.73 m²。采用Bonferroni校正来确定关联的统计学显著性。在对年龄和性别进行调整后，使用广义线性混合效应模型进行纵向分析，结果显示eGFR与甘油三酯、低密度脂蛋白胆固醇、尿酸、糖化血红蛋白含量、空腹血糖和体重指数的血清水平显著相关（P<0.0017）。随着eGFR升高，这些参数呈曲线下降。此外，eGFR与高密度脂蛋白（HDL）胆固醇的血清水平呈正相关。在对年龄和性别进行调整后，使用广义估计方程进行纵向分析表明，eGFR与高血压、2型糖尿病、低HDL胆固醇血症、高尿酸血症和肥胖的患病率之间存在显著关联（P<0.0024）。因此，低eGFR会对各种临床参数和状况产生有害影响，导致高血压、血脂异常、2型糖尿病、高尿酸血症和肥胖的风险增加。
