Zygoń Justyna, Szajewski Mariusz, Kruszewski Wiesław Janusz, Rzepko Robert
Department of General Surgery, Kościerzyna Hospital Ltd., Kościerzyna 83-400, Poland.
Department of Surgical Oncology, Gdynia Oncology Centre, PCK's Maritime Hospital in Gdynia, Gdynia 81-519, Poland; Department of Propaedeutic of Oncology, Faculty of Health Sciences, Medical University of Gdańsk, Gdynia 81-519, Poland.
Mol Clin Oncol. 2017 Feb;6(2):243-248. doi: 10.3892/mco.2016.1121. Epub 2016 Dec 30.
Angiogenesis in the primary tumor is known to be necessary for tumor progression in adenocarcinomas of the colon. However, whether angiogenesis in the primary tumors of patients with colorectal cancer affects their prognosis has yet to be fully elucidated. The aim of the present study was to assess the association between selected pathoclinical parameters and overall survival of resectable colorectal cancer patients with the expression of angiogenesis-promoting factors, including vascular endothelial growth factor (VEGF) and Fms-like tyrosine kinase receptor (Flt-1), and microvessel density (MVD) in the primary tumor. VEGF and Flt-1 expression were assessed, as well as MVD (with anti-CD34) by immunohistochemistry in 139 archived primary colorectal cancer tissue samples. These results were compared with the overall survival of the patients and potential prognostic pathoclinical parameters. A higher MVD in the tumors expressing Flt-1 (P=0.04) was identified. However, there was no correlation between the pathoclinical parameters of colon cancer and Flt-1 expression, VEGF expression, or MVD in the tumor. Furthermore, the intensity of VEGF expression, Flt-1 expression and tumor MVD did not correlate with the overall survival of the patients. Therefore, although increased expression of VEGF and Flt-1 was correlated with an increased expression of MVD in the primary tumors of resectable colorectal cancer patients, these factors were not correlated with prognostic pathoclinical factors and overall survival.
已知在结肠癌腺癌中，原发性肿瘤血管生成是肿瘤进展所必需的。然而，结直肠癌患者原发性肿瘤中的血管生成是否会影响其预后，尚未完全阐明。本研究的目的是评估可切除的结直肠癌患者的选定病理临床参数与总生存期之间的关联，以及原发性肿瘤中血管生成促进因子的表达，包括血管内皮生长因子（VEGF）和Fms样酪氨酸激酶受体（Flt-1），以及微血管密度（MVD）。通过免疫组织化学方法对139份存档的原发性结直肠癌组织样本进行了VEGF和Flt-1表达以及MVD（使用抗CD34）的评估。将这些结果与患者的总生存期以及潜在的预后病理临床参数进行比较。在表达Flt-1的肿瘤中发现了更高的MVD（P=0.04）。然而，结肠癌的病理临床参数与肿瘤中的Flt-1表达、VEGF表达或MVD之间没有相关性。此外，VEGF表达强度、Flt-1表达强度和肿瘤MVD与患者的总生存期无关。因此，虽然VEGF和Flt-1表达增加与可切除结直肠癌患者原发性肿瘤中MVD表达增加相关，但这些因素与预后病理临床因素和总生存期无关。
