Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
J Immunol Res. 2022 Jul 4;2022:7043856. doi: 10.1155/2022/7043856. eCollection 2022.
. Of all intestinal microbiome-derived metabolites, trimethylamine N-oxide (TMAO) has received increasing attention because of its potent role in colorectal cancer development. Accumulating evidence suggests that TMAO generated by the gut microbiota is a new and important player in the etiological process of colorectal cancer. Nevertheless, the carcinogenic mechanism of TMAO in colorectal cancer remains unclear. In this study, TMAO induced colorectal cancer cell proliferation and produced higher vascular endothelial growth factor A (VEGFA) levels . , after long-term choline feeding in tumor-bearing mice, circulating TMAO levels, tumor volume, new blood vessel formation, and VEGFA and CD31 amounts were increased significantly. This study revealed that TMAO exerts oncogenic effects by promoting cell proliferation and angiogenesis in colorectal cancer.
肠道微生物组衍生代谢物中，三甲基胺 N-氧化物（TMAO）由于其在结直肠癌发展中的强大作用而受到越来越多的关注。越来越多的证据表明，肠道微生物群产生的 TMAO 是结直肠癌病因过程中的一个新的重要参与者。然而，TMAO 在结直肠癌中的致癌机制尚不清楚。在这项研究中，TMAO 诱导结直肠癌细胞增殖，并产生更高水平的血管内皮生长因子 A（VEGFA）。在荷瘤小鼠长期给予胆碱后，循环 TMAO 水平、肿瘤体积、新血管形成以及 VEGFA 和 CD31 的量均显著增加。本研究表明 TMAO 通过促进结直肠癌细胞增殖和血管生成发挥致癌作用。
