Thompson Cynthia K, Walenski Matthew, Chen YuFen, Caplan David, Kiran Swathi, Rapp Brenda, Grunewald Kristin, Nunez Mia, Zinbarg Richard, Parrish Todd B
Center for the Neurobiology of Language Recovery, Northwestern University, Evanston, IL, USA; Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL, USA; Department of Neurology, Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.
Center for the Neurobiology of Language Recovery, Northwestern University, Evanston, IL, USA; Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL, USA.
Neural Plast. 2017;2017:2361691. doi: 10.1155/2017/2361691. Epub 2017 Mar 5.
Stroke-induced alterations in cerebral blood flow (perfusion) may contribute to functional language impairments and recovery in chronic aphasia. Using MRI, we examined perfusion in the right and left hemispheres of 35 aphasic and 16 healthy control participants. Across 76 regions (38 per hemisphere), no significant between-subjects differences were found in the left, whereas blood flow in the right was increased in the aphasic compared to the control participants. Region-of-interest (ROI) analyses showed a varied pattern of hypo- and hyperperfused regions across hemispheres in the aphasic participants; however, there were no significant correlations between perfusion values and language abilities in these regions. These patterns may reflect autoregulatory changes in blood flow following stroke and/or increases in general cognitive effort, rather than maladaptive language processing. We also examined blood flow in perilesional tissue, finding the greatest hypoperfusion close to the lesion (within 0-6 mm), with greater hypoperfusion in this region compared to more distal regions. In addition, hypoperfusion in this region was significantly correlated with language impairment. These findings underscore the need to consider cerebral perfusion as a factor contributing to language deficits in chronic aphasia as well as recovery of language function.
中风引起的脑血流（灌注）改变可能导致慢性失语症患者出现功能性语言障碍并影响其恢复。我们使用磁共振成像（MRI）检查了35名失语症患者和16名健康对照者左右半球的灌注情况。在76个区域（每个半球38个）中，左侧未发现受试者之间存在显著差异，而与对照参与者相比，失语症患者右侧的血流量增加。感兴趣区域（ROI）分析显示，失语症患者两侧半球的灌注不足和灌注过度区域呈现出不同的模式；然而，这些区域的灌注值与语言能力之间没有显著相关性。这些模式可能反映了中风后血流的自动调节变化和/或一般认知努力的增加，而不是适应不良的语言处理。我们还检查了病灶周围组织的血流，发现最严重的灌注不足发生在靠近病灶的区域（0 - 6毫米范围内），该区域的灌注不足比更远端的区域更严重。此外，该区域的灌注不足与语言障碍显著相关。这些发现强调了在慢性失语症中，需要将脑灌注视为导致语言缺陷以及语言功能恢复的一个因素。
