钴(III)和铑(III)催化的 C-H 酰胺化反应和 4-喹诺酮的合成：弱配位和可功能化烯胺酮辅助的 C-H 活化。
Cobalt(III)- and Rhodium(III)-Catalyzed C-H Amidation and Synthesis of 4-Quinolones: C-H Activation Assisted by Weakly Coordinating and Functionalizable Enaminone.
机构信息
Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
School of Chemistry and Chemical Engineering, Dalian University of Technology , Dalian 116023, China.
出版信息
Org Lett. 2017 Apr 7;19(7):1812-1815. doi: 10.1021/acs.orglett.7b00583. Epub 2017 Mar 30.
Cobalt(III) and rhodium(III) catalysts exhibited complementary scope in C-H amidation of aryl enaminones. The amidation reactions proceeded with broad scope under the assistance of a weakly coordinating and bifunctional enaminone directing group. The electrophilicity of the enaminone group can be further utilized in subsequent hydrolysis-cyclization reactions to afford NH 4-quinolones in telescoping reactions.
钴(III)和铑(III)催化剂在芳基烯胺酮的 C-H 酰胺化反应中表现出互补的范围。在弱配位双功能烯胺酮导向基团的辅助下，酰胺化反应具有广泛的范围。烯胺酮基团的亲电性可以进一步用于随后的水解-环化反应，以在缩合反应中提供 NH4-喹诺酮。
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