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基于纳米材料的骨再生。

Nanomaterial-based bone regeneration.

机构信息

Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.

出版信息

Nanoscale. 2017 Apr 13;9(15):4862-4874. doi: 10.1039/c7nr00835j.

Abstract

Bone diseases/injuries have been driving an urgent quest for bone substitutes for bone regeneration. Nanoscaled materials with bone-mimicking characteristics may create suitable microenvironments to guide effective bone regeneration. In this review, the natural hierarchical architecture of bone and its regeneration mechanisms are elucidated. Recent progress in the development of nanomaterials which can promote bone regeneration through bone-healing mimicry (e.g., compositional, nanocrystal formation, structural, and growth factor-related mimicking) is summarized. The nanoeffects of nanomaterials on the regulation of bone-related biological functions are highlighted. How to prepare nanomaterials with combinative bone-biomimicry features according to the bone healing process is prospected in order to achieve rapid bone regeneration in situ.

摘要

骨病/损伤一直促使人们迫切寻求用于骨再生的骨替代物。具有类似骨特征的纳米级材料可以创造合适的微环境,从而引导有效的骨再生。在本综述中,阐明了骨的天然分级结构及其再生机制。总结了在通过骨愈合模拟来促进骨再生的纳米材料的最新进展(例如组成、纳米晶体形成、结构和生长因子相关模拟)。强调了纳米材料对骨相关生物功能调控的纳米效应。为了实现原位快速骨再生,根据骨愈合过程来制备具有组合骨仿生特征的纳米材料是未来的研究方向。

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