Department of Mechanical Engineering - Engineering Mechanics, Michigan Technological University, Houghton, MI 49931, USA.
Center for Nanomedicine & Department of Anesthesiology, Brigham & Women's Hospital Harvard Medical School, Boston, MA 02115, USA.
Nanomedicine (Lond). 2019 Nov;14(22):2987-3006. doi: 10.2217/nnm-2018-0445. Epub 2019 Nov 29.
Joint replacement and bone reconstructive surgeries are on the rise globally. Current strategies for implants and bone regeneration are associated with poor integration and healing resulting in repeated surgeries. A multidisciplinary approach involving basic biological sciences, tissue engineering, regenerative medicine and clinical research is required to overcome this problem. Considering the nanostructured nature of bone, expertise and resources available through recent advancements in nanobiotechnology enable researchers to design and fabricate devices and drug delivery systems at the nanoscale to be more compatible with the bone tissue environment. The focus of this review is to present the recent progress made in the rationale and design of nanomaterials for tissue engineering and drug delivery relevant to bone regeneration.
全球范围内，关节置换和骨重建手术的数量正在上升。目前，用于植入物和骨再生的策略与较差的整合和愈合相关，导致需要反复手术。需要多学科方法，包括基础生物学、组织工程、再生医学和临床研究，以克服这个问题。考虑到骨骼的纳米结构特性，通过纳米生物技术的最新进展获得的专业知识和资源使研究人员能够设计和制造纳米级的设备和药物输送系统，使其与骨组织环境更加兼容。本综述的重点是介绍与骨再生相关的组织工程和药物输送中纳米材料的设计和应用的最新进展。
