Harder-Lauridsen Nina M, Rosenberg Astrid, Benatti Fabiana B, Damm Julie A, Thomsen Carsten, Mortensen Erik L, Pedersen Bente K, Krogh-Madsen Rikke
The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark.
The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark.
Nutrition. 2017 May;37:92-103. doi: 10.1016/j.nut.2016.12.015. Epub 2016 Dec 28.
There has been a parallel increase in the incidence of obesity and diabetes as well as the number of daily meals. However, evidence is lacking regarding the role of intermittent fasting. The aim of this study was to determine the effects of a Ramadan model of intermittent fasting (RIF; 14 h of daytime abstinence from food and drinking) for 28 d on body composition, glucose metabolism, and cognitive function.
Ten healthy, lean men were included in a nonrandomized, crossover, intervention study. Testing was performed before a control period of 28 d, as well as before and after 28 d of RIF. Whole-body dual-energy x-ray absorptiometry, magnetic resonance imaging of the abdomen, fitness test, oral glucose tolerance test, and cognitive function tests were performed. As secondary outcome, the participants' physical activity and 72-h glycemic responses were monitored 6 d within each of the periods. Dietary intake, appetite, and mood questionnaires also were assessed.
Comparing Δ differences from testing days; body mass index changes from the control period (Δ mean: 0.2 kg/m, 95% confidence interval [CI], -2 to 0.5) and the RIF period (Δ mean: -0.3 kg/m, 95% CI, -0.6 to -0.1) were significantly different (P < 0.05). Secondary outcomes within the RIF period showed an increased area under curve (AUC) for hunger accompanied by a reduced AUC for satiety (both, P < 0.05), less mean steps per day (P < 0.05), and less positive feelings in the afternoon (P < 0.01) compared with the control period. No changes were observed in any of the other evaluated parameters.
Free-living participants were able to comply with 14 h of daily daytime abstinence from food and drinking for 28 d with only a minor effect on body mass index and without any effects on body composition, glucose metabolism, and cognitive function.
肥胖症和糖尿病的发病率以及每日进餐次数都在同步上升。然而，关于间歇性禁食的作用，目前仍缺乏相关证据。本研究的目的是确定为期28天的斋月模式间歇性禁食（RIF；白天禁食禁饮14小时）对身体成分、葡萄糖代谢和认知功能的影响。
10名健康、体型偏瘦的男性被纳入一项非随机、交叉、干预性研究。在为期28天的对照期之前，以及RIF期的28天前后均进行了测试。进行了全身双能X线吸收测定、腹部磁共振成像、体能测试、口服葡萄糖耐量测试和认知功能测试。作为次要结果，在每个时期内的6天时间里监测了参与者的身体活动和72小时血糖反应。还评估了饮食摄入量、食欲和情绪问卷。
比较测试日的变化差异；对照期的体重指数变化（平均变化：0.2kg/m，95%置信区间[CI]，-2至0.5）和RIF期的体重指数变化（平均变化：-0.3kg/m，95%CI，-0.6至-0.1）有显著差异（P<0.05）。与对照期相比，RIF期的次要结果显示饥饿曲线下面积（AUC）增加，饱腹感AUC降低（两者均P<0.05），每天平均步数减少（P<0.05），下午的积极情绪减少（P<0.01）。在其他任何评估参数中均未观察到变化。
自由生活的参与者能够在28天内每天白天禁食禁饮14小时，对体重指数只有轻微影响，且对身体成分、葡萄糖代谢和认知功能没有任何影响。
