College of Animal Sciences, Jilin University, Changchun, China.
College of Animal Sciences, Jilin University, Changchun, China.
Clin Chim Acta. 2017 Jun;469:87-93. doi: 10.1016/j.cca.2017.03.025. Epub 2017 Mar 27.
Retinoids (retinol and its derivatives) are required for maintaining vision, immunity, barrier function, reproduction, embryogenesis, cell proliferation and differentiation. Furthermore, retinoid signaling plays a key role in initiating meiosis of germ cells of the mammalian fetal ovary. Recently, studies indicated that precise retinoid level regulation in the ovary provides a molecular control of ovarian development, steroidogenesis and oocyte maturation. Besides, abnormal retinoid signaling may be involved in the pathogenesis of polycystic ovary syndrome (PCOS), one of the most common ovarian endocrinopathies in reproductive-aged women worldwide. This review primarily summarizes recent advancements made in investigating the action of retinoid signaling in ovarian physiology as well as the abnormal retinoid signaling in PCOS.
类视黄醇（视黄醇及其衍生物）是维持视觉、免疫、屏障功能、生殖、胚胎发生、细胞增殖和分化所必需的。此外，类视黄醇信号在启动哺乳动物胎儿卵巢生殖细胞减数分裂中起着关键作用。最近的研究表明，卵巢中精确的类视黄醇水平调节为卵巢发育、类固醇生成和卵母细胞成熟提供了分子控制。此外，异常的类视黄醇信号可能参与多囊卵巢综合征（PCOS）的发病机制，PCOS 是全球生殖年龄妇女中最常见的卵巢内分泌疾病之一。本综述主要总结了近年来在研究类视黄醇信号在卵巢生理学中的作用以及 PCOS 中异常类视黄醇信号方面的进展。
