Azizieh Fawaz Y, Alyahya Khulood O, Dingle Kamaludin
Department of Mathematics and Natural Sciences, Gulf University for Science and Technology, International Centre for Applied Mathematics and Computational Bioengineering, West Mishref, Kuwait.
Science Department, College of Basic Education, Public Authority for Applied Education and Training, Kuwait City, Kuwait.
J Inflamm Res. 2017 Mar 17;10:19-28. doi: 10.2147/JIR.S127892. eCollection 2017.
Although a large number of studies have investigated possible relationships among serum levels of vitamin D or cytokines with disease progress and prognosis, similar studies on self-reported symptoms are still controversial. The overall objective of this study was to look into the association between serum levels of vitamin D or cytokines with self-reported symptoms related to musculoskeletal pain, sleep disorders, and premenstrual syndrome (PMS) in healthy adult women.
Venous blood samples were collected from 117 healthy adult women, and serum levels of vitamin D, pro-inflammatory cytokines (IL-1β, IL-6, IL-8, IL-17, IFN-γ, and TNF-α) and anti-inflammatory cytokines (IL-4, IL-10, and IL-13) were measured. Groups were tested for differences in single parameters, pro-:anti-inflammatory cytokine ratios, and differences in multivariate patterns.
There were no significant associations between serum levels of vitamin D and any of the self-reported symptoms studied. However, serum levels of certain pro-inflammatory cytokines were significantly higher in subjects with musculoskeletal pain (IL-8, =0.008), sleep disorders (IFN-γ, =0.02), and PMS (IL-8 and TNF-α, =0.009 and 0.002, respectively) compared to subjects who reported no symptoms. The pro-:anti-inflammatory cytokine ratios showed pro-inflammatory cytokine dominance in subjects with self-reported symptoms, particularly in the groups with deficient levels of vitamin D. However, the multivariate cytokine-pattern analysis was significantly different between PMS groups only.
These data point to a possible role of pro-inflammatory cytokines as a contributing factor in self-reported symptoms related to musculoskeletal pain, sleep disorders, and PMS.
尽管大量研究调查了维生素D或细胞因子血清水平与疾病进展及预后之间的可能关系，但关于自我报告症状的类似研究仍存在争议。本研究的总体目标是探究健康成年女性血清中维生素D或细胞因子水平与自我报告的与肌肉骨骼疼痛、睡眠障碍和经前综合征（PMS）相关症状之间的关联。
采集了117名健康成年女性的静脉血样本，检测血清中维生素D、促炎细胞因子（IL-1β、IL-6、IL-8、IL-17、IFN-γ和TNF-α）和抗炎细胞因子（IL-4、IL-10和IL-13）的水平。对各组的单一参数、促炎与抗炎细胞因子比值以及多变量模式的差异进行了检测。
维生素D血清水平与所研究的任何自我报告症状之间均无显著关联。然而，与未报告症状的受试者相比，肌肉骨骼疼痛患者（IL-8，P = 0.008）、睡眠障碍患者（IFN-γ，P = 0.02）和PMS患者（IL-8和TNF-α，P分别为0.009和0.002）的某些促炎细胞因子血清水平显著更高。促炎与抗炎细胞因子比值显示，自我报告有症状的受试者中促炎细胞因子占主导，尤其是维生素D水平不足的组。然而，仅PMS组之间的多变量细胞因子模式分析存在显著差异。
这些数据表明促炎细胞因子可能是与肌肉骨骼疼痛、睡眠障碍和PMS相关的自我报告症状的一个促成因素。
