Aryafar Mohamad, Gholami Farshid, Bozorgmehr Rama
Department of Anesthesiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University.
Clinical Research Development Unit, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ann Med Surg (Lond). 2023 Jul 26;85(9):4262-4267. doi: 10.1097/MS9.0000000000000955. eCollection 2023 Sep.
Prognosis of COVID-19 infection has been indicated to be associated with vitamin D status and ABO blood group. However, owing to discrepancies and an increased number of cases globally, the findings remain unclear. This study aimed to evaluate the association between vitamin D and ABO blood group systems in patients with severe COVID-19.
In this cross-sectional study, COVID-19 patients referred to two hospitals in the capital of Iran, Tehran, admitted to the ICU ward due to the severity of COVID-19 were evaluated. Serum vitamin D and ABO levels were evaluated in these patients. The data obtained were statistically analyzed using SPSSv24.
Of 305 patients, 33.1% patients had O+ blood type, 27.8% had A+ blood type and 22.4% had B+ blood type. Vitamin D deficiency was significantly associated with a mortality rate among these patients, <0.05. The blood group of the patients was not correlated with mortality. Thirty-seven percent of the patients in the study died because of COVID-19.
In our study population, mortality due to COVID-19 was significantly associated with vitamin D deficiency but not the ABO blood group. We recommend further studies in this regard that include more variable and detailed biochemical analysis.
已有研究表明，新型冠状病毒肺炎（COVID-19）感染的预后与维生素D水平和ABO血型有关。然而，由于全球范围内研究结果存在差异且病例数不断增加，这些发现仍不明确。本研究旨在评估重症COVID-19患者中维生素D与ABO血型系统之间的关联。
在这项横断面研究中，对转诊至伊朗首都德黑兰两家医院、因COVID-19病情严重而入住重症监护病房的患者进行了评估。对这些患者的血清维生素D水平和ABO血型进行了评估。使用SPSSv24对获得的数据进行统计学分析。
在305例患者中，33.1%为O+血型，27.8%为A+血型，22.4%为B+血型。维生素D缺乏与这些患者的死亡率显著相关，P<0.05。患者的血型与死亡率无关。本研究中37%的患者死于COVID-19。
在我们的研究人群中，COVID-19导致的死亡与维生素D缺乏显著相关，但与ABO血型无关。我们建议在这方面开展进一步研究，包括更具变量性和详细的生化分析。
