舍曲林对焦虑症儿童及青少年生活质量的影响。
The Effect of Sertraline on the Quality of Life for Children and Adolescents with Anxiety Disorder.
作者信息
Çakin Memik Nursu, Karakaya Işık, Yildiz Özlem, Şişmanlar Şahika, Çağlayan Çiğdem, Ağaoğlu Belma
机构信息
Kocaeli University Faculty of Medicine, Child and Adolescent Mental Health and Department of Medicine, Kocaeli, Turkey.
Kocaeli University Faculty of Medicine, Department of Public Health, Kocaeli, Turkey.
出版信息
Noro Psikiyatr Ars. 2014 Mar;51(1):30-39. doi: 10.4274/npa.y6565. Epub 2014 Mar 1.
INTRODUCTION
In this study, we aimed to determine the changes in quality of life of children/adolescents with anxiety disorders during six months of sertraline treatment, to investigate parent-child/adolescent concordance in perception of quality of life and to examine the effect of treatment on children/adolescents.
METHODS
In this study, 30 patients with anxiety disorders according to criteria specified in Diagnostic and Statistical Manual of Mental Disorders, 4. Edition (DSM-IV) were assigned to sertraline treatment. The patients were evaluated using the Pediatric Quality of Life Inventory (PedsQL), State-Trait Anxiety Inventory for Children, Clinical Global Impression Scale (CGI) and the Children's Global Assessment Scale (CGAS) at 0th, 2 and 6 months.
RESULTS
PedsQL total scores increased significantly with the treatment in children and adolescents (p<.001), however, no differences were observed in parent proxy report (p=.326). The mean CGAS score was 59.85±7.73 at the beginning of treatment and 73.70±7.01 at the end of treatment (p<.001). The average CGI score decreased from 4.68±.96 to 2.27±.84.
CONCLUSION
It was observed that perception of quality of life in children and adolescents with anxiety disorders increased with the treatment.
引言
在本研究中，我们旨在确定患有焦虑症的儿童/青少年在接受舍曲林治疗六个月期间生活质量的变化，调查亲子/青少年在生活质量认知方面的一致性，并研究治疗对儿童/青少年的影响。
方法
在本研究中，30名符合《精神疾病诊断与统计手册》第4版（DSM-IV）标准的焦虑症患者被分配接受舍曲林治疗。在第0、2和6个月时，使用儿童生活质量量表（PedsQL）、儿童状态-特质焦虑量表、临床总体印象量表（CGI）和儿童总体评估量表（CGAS）对患者进行评估。
结果
儿童和青少年的PedsQL总分在治疗后显著增加（p<.001），然而，在家长代理报告中未观察到差异（p=.326）。治疗开始时CGAS平均评分为59.85±7.73，治疗结束时为73.70±7.01（p<.001）。CGI平均评分从4.68±.96降至2.27±.84。
结论
观察到患有焦虑症的儿童和青少年的生活质量认知随着治疗而提高。
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