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本文引用的文献

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Correlation between Serum D-Dimer Level and Volume in Acute Ischemic Stroke.急性缺血性脑卒中患者血清D-二聚体水平与梗死体积的相关性
J Korean Neurosurg Soc. 2011 Aug;50(2):89-94. doi: 10.3340/jkns.2011.50.2.89. Epub 2011 Aug 31.
2
Oxfordshire community stroke project classification poorly differentiates small cortical and subcortical infarcts.牛津郡社区卒中项目分类法对小皮质和皮质下梗死的区分较差。
Stroke. 2011 Aug;42(8):2143-8. doi: 10.1161/STROKEAHA.111.613752. Epub 2011 Jun 23.
3
Neuron-specific enolase and S 100B protein as predictors of outcome in ischaemic stroke.神经元特异性烯醇化酶和 S100B 蛋白作为缺血性脑卒中预后的预测因子。
Neurol Neurochir Pol. 2010 Sep-Oct;44(5):459-63. doi: 10.1016/s0028-3843(14)60136-5.
4
Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke.系统性炎症标志物与 S100B 浓度独立相关：急性缺血性脑卒中患者观察性研究的结果。
J Neuroinflammation. 2010 Oct 29;7:71. doi: 10.1186/1742-2094-7-71.
5
Neurobiochemical markers of brain damage in cerebrospinal fluid of acute ischemic stroke patients.急性缺血性脑卒中患者脑脊液中脑损伤的神经生物化学标志物。
Clin Chem. 2010 Mar;56(3):451-8. doi: 10.1373/clinchem.2009.134122. Epub 2009 Dec 3.
6
[Changes of protein S100B serum concentration during ischemic and hemorrhagic stroke in relation to the volume of stroke lesion].[缺血性和出血性卒中期间血清S100B蛋白浓度变化与卒中病灶体积的关系]
Neurol Neurochir Pol. 2005 Jul-Aug;39(4):310-7.
7
Evaluation of serum S100B as a surrogate marker for long-term outcome and infarct volume in acute middle cerebral artery infarction.评估血清S100B作为急性大脑中动脉梗死长期预后和梗死体积替代标志物的价值。
Arch Neurol. 2005 Jul;62(7):1130-4. doi: 10.1001/archneur.62.7.1130.
8
Release of neurobiochemical markers of brain damage is related to the neurovascular status on admission and the site of arterial occlusion in acute ischemic stroke.脑损伤神经生化标志物的释放与急性缺血性卒中入院时的神经血管状况及动脉闭塞部位有关。
J Neurol Sci. 2004 Dec 15;227(1):49-53. doi: 10.1016/j.jns.2004.08.005.
9
Serum S-100B protein as a molecular marker in severe traumatic brain injury.血清S-100B蛋白作为重度创伤性脑损伤的分子标志物。
Restor Neurol Neurosci. 2003;21(3-4):159-69.
10
S100B in brain damage and neurodegeneration.脑损伤和神经退行性变中的S100B蛋白
Microsc Res Tech. 2003 Apr 15;60(6):614-32. doi: 10.1002/jemt.10303.

急性缺血性卒中患者血清S100B水平与梗死面积及临床结局的关系

The Relationship of Serum S100B Levels with Infarction Size and Clinical Outcome in Acute Ischemic Stroke Patients.

作者信息

Selçuk Özlem, Yayla Vildan, Çabalar Murat, Güzel Vildan, Uysal Samiye, Gedikbaşi Asuman

机构信息

Bulanık State Hospital, Neurology Clinics, Muş, Turkey.

Bakırköy Dr. Sadi Konuk Education and Research Hospital, Neurology Clinics, İstanbul, Turkey.

出版信息

Noro Psikiyatr Ars. 2014 Dec;51(4):395-400. doi: 10.5152/npa.2014.7213. Epub 2014 Dec 1.

DOI:10.5152/npa.2014.7213
PMID:28360660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5353176/
Abstract

INTRODUCTION

S100B protein, which helps nerve development and differentiation, is produced by astrocytes and can be detected in peripheral circulation after brain damage. In this study, we aimed to investigate the relationship between the serum S100B protein level and the infarction volume and clinical outcome and also the early prognostic role of serum S100B protein in patients with ischemic stroke.

METHOD

Fifty patients admitted in the first 24-hour period of acute ischemic stroke were evaluated prospectively, and the findings were compared to those of the controls (n=26). S100B levels of the patients and neurological findings on days 1, 3, and 5 and their functional outcomes on the discharge day and at the first month were recorded by the same examiner.

RESULTS

S100B levels were not affected by sex, age, or concomitant systemic diseases. The maximum levels of S100B were recorded on the 3 day, and there was a correlation between infarct size and S100B levels. No correlation between the severity of stroke and S100B level was found. There was a poor correlation between the functional outcomes of the patients at the 1 month and S100B levels and on the 3 day.

CONCLUSION

The detection of high S100B levels in peripheral circulation after acute ischemic stroke and the correlations of S100B levels with infarct size (good) and disability (poor) imply that S100B protein may be used as a peripheral marker in acute ischemic stroke patients.

摘要

引言

S100B蛋白由星形胶质细胞产生，有助于神经发育和分化，脑损伤后可在外周循环中检测到。在本研究中，我们旨在探讨血清S100B蛋白水平与梗死体积及临床结局之间的关系，以及血清S100B蛋白在缺血性卒中患者中的早期预后作用。

方法

对50例在急性缺血性卒中发病后24小时内入院的患者进行前瞻性评估，并将结果与对照组（n = 26）进行比较。由同一名检查者记录患者在第1、3和5天的S100B水平、神经学检查结果以及出院日和第1个月时的功能结局。

结果

S100B水平不受性别、年龄或伴随的全身性疾病影响。S100B的最高水平记录在第3天，梗死面积与S100B水平之间存在相关性。未发现卒中严重程度与S100B水平之间存在相关性。患者在第1个月时的功能结局与第3天的S100B水平之间相关性较差。

结论

急性缺血性卒中后外周循环中S100B水平升高，以及S100B水平与梗死面积（良好）和残疾（较差）之间的相关性表明，S100B蛋白可作为急性缺血性卒中患者的外周标志物。