Özkan Adile, Altinbaş Kürşat, Koç Emine Rabia, Şen Halil Murat, Özişik Karaman Handan Işın
Department of Neurology, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale, Turkey.
Department of Psychiatry, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale, Turkey.
Noro Psikiyatr Ars. 2016 Dec;53(4):311-316. doi: 10.5152/npa.2015.12393. Epub 2015 Oct 22.
The aim of the present study was to screen for bipolarity and to investigate the affective temperaments of patients with multiple sclerosis (MS) and the possible association between the clinical and demographic characteristics of MS patients and temperament profiles.
A total of 65 patients with MS and 66 healthy volunteers completed the 32-item hypomania checklist (HCl-32), the Mood Disorder Questionnaire (MDQ), and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A) tests. The HCl-32, MDQ, and TEMPS-A scores were compared between the patients and healthy volunteers.
MS patients had significantly higher scores for the depressive, cyclothymic, irritable, and anxious domains of the TEMPS-A scale than the control group, whereas relapsing remitting MS (RRMS) patients had higher MDQ and TEMPS-A hyperthymia scores than secondary progressive MS patients. MS patients who were being treated with interferon beta 1-b therapy had significantly higher MDQ scores than those being treated with interferon beta 1-a, glatiramer acetate, or who were without medication. Expanded Disability Status Scale (EDSS) scores were positively correlated with TEMPS-A depressive and hyperthymic temperaments.
Our results suggest that higher scores for affective temperament in MS patients indicate subclinical manifestations of mood disorders. Higher hyperthymia scores and manic symptoms detected in the RRMS group could shed light on the relationship between bipolarity and MS. Thus, the screening of bipolarity and affective temperament profiles in MS patients could help clinicians predict future mood episodes and decrease their impact on disease severity.
本研究旨在筛查双相情感障碍，并调查多发性硬化症（MS）患者的情感气质，以及MS患者的临床和人口统计学特征与气质类型之间的可能关联。
共有65例MS患者和66名健康志愿者完成了32项轻躁狂检查表（HCl-32）、心境障碍问卷（MDQ）以及孟菲斯、比萨、巴黎和圣地亚哥气质评估-自陈问卷（TEMPS-A）测试。比较了患者与健康志愿者之间的HCl-32、MDQ和TEMPS-A得分。
MS患者在TEMPS-A量表的抑郁、环性心境、易怒和焦虑维度上的得分显著高于对照组，而复发缓解型MS（RRMS）患者的MDQ和TEMPS-A轻躁狂得分高于继发进展型MS患者。接受β-1b干扰素治疗的MS患者的MDQ得分显著高于接受β-1a干扰素、醋酸格拉替雷治疗或未用药的患者。扩展残疾状态量表（EDSS）得分与TEMPS-A抑郁和轻躁狂气质呈正相关。
我们的结果表明，MS患者情感气质得分较高表明存在心境障碍的亚临床症状。RRMS组中检测到的较高轻躁狂得分和躁狂症状可能有助于阐明双相情感障碍与MS之间的关系。因此，筛查MS患者的双相情感障碍和情感气质类型有助于临床医生预测未来的情绪发作，并降低其对疾病严重程度的影响。
