Samartzis Lampros, Gavala Efthymia, Zoukos Yiannis, Aspiotis Achilleas, Thomaides Thomas
Department of Neurology, General Hospital of the Greek Red Cross "Korgialeneio-Benakeio", Athens, Greece ; Department of Psychiatry, Athalassa Mental Health Hospital, Nicosia, Cyprus ; St. George's University of London Medical School, University of Nicosia, Nicosia, Cyprus.
Department of Neurology, General Hospital of the Greek Red Cross "Korgialeneio-Benakeio", Athens, Greece.
Rehabil Res Pract. 2014;2014:128751. doi: 10.1155/2014/128751. Epub 2014 Sep 1.
Background/Aim. The aim of this study is to examine the effects of perceived cognitive dysfunction and of depression, on self-reported QoL, in a Greek population sample of MS patients. Methods. One hundred outpatients diagnosed with MS completed the Short-Form-36 Health Survey (SF-36), as well as the Perceived Deficits Questionnaire (PDQ) and the Depression subscale of the Mental Health Inventory (MHI), as part of a clinical evaluation which included the Expanded Disability Status Scale (EDSS) estimation. Multiple linear regression was conducted to determine the best linear combination of age, gender, education, EDSS, depression, attention/concentration, retrospective memory, prospective memory, and planning/organization, for predicting QoL scores. Results. In the multivariate regression analysis models, EDSS (P < 0.05), depression (P < 0.001), perceived planning/organization (P < 0.05), and perceived retrospective memory dysfunction (P < 0.05) independently predict quality of life scores. Age, sex, education level, and perceived attention/concentration dysfunction, as well as perceived prospective memory dysfunction, do not independently predict quality of life scores. Conclusions. Perceived planning/organization impairment and perceived retrospective memory impairment in MS patients predict QoL independently of the severity of disease and the severity of depression and therefore should be considered in the assessment of patient health status as well as in the design of treatment interventions and rehabilitation.
背景/目的。本研究旨在调查希腊多发性硬化症（MS）患者样本中，认知功能障碍感和抑郁对自我报告的生活质量（QoL）的影响。方法。100名被诊断为MS的门诊患者完成了简明健康调查量表（SF-36），以及感知缺陷问卷（PDQ）和心理健康量表（MHI）中的抑郁分量表，这是包括扩展残疾状态量表（EDSS）评估在内的临床评估的一部分。进行多元线性回归以确定年龄、性别、教育程度、EDSS、抑郁、注意力/集中力、回顾性记忆、前瞻性记忆和计划/组织能力的最佳线性组合，用于预测生活质量得分。结果。在多元回归分析模型中，EDSS（P < 0.05）、抑郁（P < 0.001）、感知到的计划/组织能力（P < 0.05）和感知到的回顾性记忆功能障碍（P < 0.05）独立预测生活质量得分。年龄、性别、教育水平、感知到的注意力/集中力功能障碍以及感知到的前瞻性记忆功能障碍不能独立预测生活质量得分。结论。MS患者感知到的计划/组织能力损害和感知到的回顾性记忆损害独立于疾病严重程度和抑郁严重程度预测生活质量，因此在评估患者健康状况以及设计治疗干预和康复方案时应予以考虑。
