Kwok Janice, O'Shea Marie, Hume David A, Lengeling Andreas
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh Edinburgh, UK.
Front Genet. 2017 Mar 16;8:32. doi: 10.3389/fgene.2017.00032. eCollection 2017.
Lysyl hydroxylation and arginyl demethylation are post-translational events that are important for many cellular processes. The jumonji domain containing protein 6 (JMJD6) has been reported to catalyze both lysyl hydroxylation and arginyl demethylation on diverse protein substrates. It also interacts directly with RNA. This review summarizes knowledge of JMJD6 functions that have emerged in the last 15 years and considers how a single Jumonji C (JmjC) domain-containing enzyme can target so many different substrates. New links and synergies between the three main proposed functions of Jmjd6 in histone demethylation, promoter proximal pause release of polymerase II and RNA splicing are discussed. The physiological context of the described molecular functions is considered and recently described novel roles for JMJD6 in cancer and immune biology are reviewed. The increased knowledge of JMJD6 functions has wider implications for our general understanding of the JmjC protein family of which JMJD6 is a member.
赖氨酰羟基化和精氨酰去甲基化是对许多细胞过程都很重要的翻译后事件。据报道，含jumonji结构域蛋白6（JMJD6）可催化多种蛋白质底物上的赖氨酰羟基化和精氨酰去甲基化。它还直接与RNA相互作用。本综述总结了过去15年中出现的关于JMJD6功能的知识，并思考了一种含单个Jumonji C（JmjC）结构域的酶如何能够作用于如此多不同的底物。讨论了Jmjd6在组蛋白去甲基化、聚合酶II启动子近端暂停释放和RNA剪接这三个主要假定功能之间的新联系和协同作用。考虑了所描述分子功能的生理背景，并综述了最近报道的JMJD6在癌症和免疫生物学中的新作用。对JMJD6功能的更多了解对我们对JMJD6所属的JmjC蛋白家族的总体理解具有更广泛的意义。
