College of Photonics, National Chiao Tung University, Tainan 711, Taiwan.
Department of Physics, National Taiwan University, Taipei 10617, Taiwan.
Sci Rep. 2017 Mar 31;7:45503. doi: 10.1038/srep45503.
Clinoptilolite type of zeolite (CZ) is a promising material for biomedicine and pharmaceutics due to its non-toxicity, thermal stability, expanded surface area, and exceptional ability to adsorb various atoms and organic molecules into micropores. Using multiphoton microscopy, we demonstrated that individual CZ particles produce two-photon excited luminescence and second harmonic generation signal at femtosecond laser excitation, and adsorb photo-dynamically active dyes such as hypericin and methylene blue. Furthermore, the release of hypericin from CZ pores in the presence of biomolecules is shown, and CZ can be considered as an effective material for drug delivery and controlled release in biological systems. The results may open new perspectives in application of CZ in biomedical imaging, and introducing of the optical approaches into the clinical environment.
沸石的斜发沸石（CZ）类型由于其无毒、热稳定性、扩展的表面积和非凡的吸附各种原子和有机分子进入微孔的能力，是生物医药和药物学的有前途的材料。使用多光子显微镜，我们证明了单个 CZ 颗粒在飞秒激光激发下产生双光子激发荧光和二次谐波产生信号，并吸附光动力活性染料如金丝桃素和亚甲蓝。此外，还显示了在生物分子存在下 CZ 孔中金丝桃素的释放，并且 CZ 可以被认为是在生物系统中用于药物递送和控制释放的有效材料。这些结果可能在 CZ 在生物医学成像中的应用方面开辟新的视角，并将光学方法引入临床环境。
