Tian Xue, Zhang Chao, Xu Qi, Li Zhong, Shao Xusheng
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China.
Org Biomol Chem. 2017 Apr 11;15(15):3320-3323. doi: 10.1039/c6ob02813f.
Benzoylphenylureas (BPUs) are used as synthetic insect growth regulators for inhibiting chitin synthesis. Merging insecticidal BPUs with photoswitchable azobenzene generated photoresponsive chitin synthesis inhibitors. A prepared azobenzene-benzoylphenylurea can be activated upon irradiation with UV light, and shows 6-fold and 2-fold activity difference to armyworm (Mythimna separata) and German cockroach (Blattella germanica) sulfonylurea receptors, respectively. This is the first example of a photoswitchable BPU insecticide. The generation of such a photoresponsive BPU insecticide allows for modulation of the insecticidal activity by light, and may facilitate the spatiotemporal control over the sulfonylurea receptor and the mechanistic study of this kind of insecticide.
苯甲酰基苯基脲（BPUs）用作抑制几丁质合成的合成昆虫生长调节剂。将具有杀虫作用的BPUs与可光开关的偶氮苯合并，生成了光响应性几丁质合成抑制剂。制备的偶氮苯 - 苯甲酰基苯基脲在紫外光照射下可被激活，对粘虫（Mythimna separata）和德国小蠊（Blattella germanica）的磺酰脲受体分别表现出6倍和2倍的活性差异。这是可光开关的BPU杀虫剂的首个实例。这种光响应性BPU杀虫剂的产生使得能够通过光调节杀虫活性，并可能有助于对磺酰脲受体进行时空控制以及对这类杀虫剂进行机理研究。
