Kuttan R
Amala Cancer Research Centre, Amala Nagar, Trichur.
Indian J Physiol Pharmacol. 1987 Oct-Dec;31(4):245-9.
Human synovial cells from cases of rheumatoid and osteoarthritis were cultured and at their 3-5 passages, were treated with gold thiomalate. At early-log phase gold thiomalate arrested the proliferation of cells. However, at confluent state shere was a slight proliferation of synovial cells. This was followed by an increase in prolyl hydroxylase, collagen and protein synthesis, indicating that gold salts directly stimulate the synovial cells.
从类风湿性关节炎和骨关节炎患者身上获取人滑膜细胞进行培养，在传代3 - 5次时，用硫代苹果酸金进行处理。在对数早期阶段，硫代苹果酸金抑制细胞增殖。然而，在汇合状态时，滑膜细胞有轻微增殖。随后脯氨酰羟化酶、胶原蛋白和蛋白质合成增加，表明金盐直接刺激滑膜细胞。
