Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pharmaceutical Biotechnology and Isfahan Pharmaceutical Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Carbohydr Polym. 2017 Jun 1;165:322-333. doi: 10.1016/j.carbpol.2017.02.067. Epub 2017 Feb 20.
Metastasis is the main problem in successful treatment of many types of cancer such as melanoma. The extracellular matrix degradation has a crucial role in the cancer metastasis. Nanofibers can mimic the structure of extracellular matrix and limit the cancer cells migration if they are implanted in and around the tumors. Moreover, local delivery of anti-metastatic drugs such as metformin to tumor can be useful. In this study, Metformin surface modified cellulose nanofibers (Met-Cel-NFs) were successfully prepared by attachment of metformin on the surface of cellulose nanofibers through electrostatic interaction. FTIR spectroscopy and zeta potential of Met-Cel-NFs proved the occurrence of this attachment. SEM images showed the nanofibrous structure of Met-Cel-NFs. Met-Cel-NFs significantly suppressed the migration of melanoma cells. Additionally the sufficient adhesion of the melanoma cells on the Met-Cel-NFs can decrease melanoma cells invasion. Therefore, Met-Cel-NFs present a promising approach to the prevention of melanoma metastasis.
转移是许多类型癌症（如黑色素瘤）成功治疗的主要问题。细胞外基质的降解在癌症转移中起着关键作用。纳米纤维可以模拟细胞外基质的结构，如果将其植入肿瘤内部和周围，就可以限制癌细胞的迁移。此外，局部递送二甲双胍等抗转移药物到肿瘤部位也可能是有用的。在这项研究中，通过静电相互作用将二甲双胍附着在纤维素纳米纤维表面，成功制备了表面修饰二甲双胍的纤维素纳米纤维（Met-Cel-NFs）。FTIR 光谱和 Zeta 电位证明了这种附着的发生。SEM 图像显示了 Met-Cel-NFs 的纳米纤维结构。Met-Cel-NFs 显著抑制了黑色素瘤细胞的迁移。此外，黑色素瘤细胞在 Met-Cel-NFs 上的充分黏附可以减少黑色素瘤细胞的侵袭。因此，Met-Cel-NFs 为预防黑色素瘤转移提供了一种有前途的方法。
