Piscaglia Fabio, Salvatore Veronica, Mulazzani Lorenzo, Cantisani Vito, Colecchia Antonio, Di Donato Roberto, Felicani Cristina, Ferrarini Alessia, Gamal Nesrine, Grasso Valentina, Marasco Giovanni, Mazzotta Elena, Ravaioli Federico, Ruggieri Giacomo, Serio Ilaria, Sitouok Nkamgho Joules Fabrice, Serra Carla, Festi Davide, Schiavone Cosima, Bolondi Luigi
Department of Medical and Surgical Sciences, University of Bologna, Italy.
Department of Medical and Surgical Sciences, University of Bologna, Italy.
Dig Liver Dis. 2017 Jul;49(7):802-808. doi: 10.1016/j.dld.2017.03.001. Epub 2017 Mar 10.
Whether Fibroscan thresholds can be immediately adopted for none, some or all other shear wave elastography techniques has not been tested. The aim of the present study was to test the concordance of the findings obtained from 7 of the most recent ultrasound elastography machines with respect to Fibroscan.
Sixteen hepatitis C virus-related patients with fibrosis ≥2 and having reliable results at Fibroscan were investigated in two intercostal spaces using 7 different elastography machines. Coefficients of both precision (an index of data dispersion) and accuracy (an index of bias correction factors expressing different magnitudes of changes in comparison to the reference) were calculated.
Median stiffness values differed among the different machines as did coefficients of both precision (range 0.54-0.72) and accuracy (range 0.28-0.87). When the average of the measurements of two intercostal spaces was considered, coefficients of precision significantly increased with all machines (range 0.72-0.90) whereas of accuracy improved more scatteredly and by a smaller degree (range 0.40-0.99).
The present results showed only moderate concordance of the majority of elastography machines with the Fibroscan results, preventing the possibility of the immediate universal adoption of Fibroscan thresholds for defining liver fibrosis staging for all new machines.
尚未对Fibroscan阈值是否可立即应用于其他部分或全部剪切波弹性成像技术进行测试。本研究的目的是测试7种最新超声弹性成像设备与Fibroscan所得结果的一致性。
对16例丙型肝炎病毒相关纤维化≥2且Fibroscan结果可靠的患者，在两个肋间间隙使用7种不同的弹性成像设备进行检查。计算了精密度系数（数据离散度指标）和准确度系数（偏差校正因子指标，用于表示与参考值相比不同程度的变化）。
不同设备的中位硬度值不同，精密度系数（范围0.54 - 0.72）和准确度系数（范围0.28 - 0.87）也不同。当考虑两个肋间间隙测量值的平均值时，所有设备的精密度系数均显著增加（范围0.72 - 0.90），而准确度系数的改善则较为分散且程度较小（范围0.40 - 0.99）。
目前的结果表明，大多数弹性成像设备与Fibroscan结果仅具有中等程度的一致性，这使得无法立即将Fibroscan阈值普遍应用于所有新设备来定义肝纤维化分期。
