Heading Robert C
School of Medicine, Pharmacy and Health, Durham University, Durham, UK.
Clin Med (Lond). 2017 Apr;17(2):132-136. doi: 10.7861/clinmedicine.17-2-132.
Some patients with gastro-oesophageal reflux disease (GORD) experience symptoms despite proton pump inhibitor (PPI) treatment. In the early years of their availability, these drugs were thought to be a highly effective treatment for GORD and realisation that symptom relief was often incomplete came as a disappointment. This review considers the evolution of thinking with the aid of the Gartner hype cycle - a graphical depiction of the process of innovation, evolution and adoption of new technologies. Acknowledging that over-simplistic concepts of GORD have been largely responsible for inflated expectations of PPI therapy is an important step forward in establishing how patients with persistent symptoms, despite PPIs, should be assessed and treated.
一些患有胃食管反流病(GORD)的患者在接受质子泵抑制剂(PPI)治疗后仍有症状。在这些药物问世的早期,人们认为它们是治疗GORD的高效药物,而后来意识到症状缓解往往并不完全,这让人失望。本综述借助Gartner炒作周期(一种对新技术创新、演变和采用过程的图形描述)来考量观念的演变。认识到对GORD过于简单化的概念在很大程度上导致了对PPI治疗的过高期望,这是在确定如何评估和治疗尽管使用了PPI但仍有持续症状的患者方面向前迈出的重要一步。