口服西洛他唑可增加糖尿病视网膜病变患者的眼部血流量。

Oral Administration of Cilostazol Increases Ocular Blood Flow in Patients with Diabetic Retinopathy.

作者信息

Hwang Duck Jin, Shin Joo Young, Yu Hyeong Gon

机构信息

Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.; HanGil Eye Hospital, Incheon, Korea.

Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

出版信息

Korean J Ophthalmol. 2017 Apr;31(2):123-131. doi: 10.3341/kjo.2017.31.2.123. Epub 2017 Mar 21.

DOI:10.3341/kjo.2017.31.2.123

PMID:28367040

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5368085/

Abstract

PURPOSE

To investigate the effect of cilostazol on ocular hemodynamics and to determine whether the administration of cilostazol increases the ocular blood flow in patients with diabetic retinopathy.

METHODS

This prospective observational study investigated the effect of orally administered cilostazol on diabetic retinopathy. Before and after administration for 1 week, pulsatile ocular blood flow (POBF) and retrobulbar hemodynamics were measured using a POBF analyzer and transcranial Doppler imaging, respectively. Visual acuity, intraocular pressure, and blood pressure were also evaluated before and after treatment.

RESULTS

Twenty-five eyes of 25 patients were included in this study. POBF increased significantly (16.8 ± 4.6 µL/sec vs. 19.6 ± 6.2 µL/sec, < 0.001) after administration of cilostazol, while no significant change was identified in visual acuity, intraocular pressure, and blood pressure. Mean flow velocity in the ophthalmic artery as measured with transcranial Doppler imaging also increased significantly after medication (23.5 ± 5.6 cm/sec vs. 26.0 ± 6.9 cm/sec, = 0.001). The change in POBF directly correlated with the change in mean flow velocity (r = 0.419, = 0.007).

CONCLUSIONS

Cilostazol was effective in increasing ocular blood flow in patients with diabetic retinopathy, possibly by modulating retrobulbar circulation.

摘要

目的

研究西洛他唑对眼部血流动力学的影响，并确定西洛他唑给药是否能增加糖尿病视网膜病变患者的眼部血流量。

方法

这项前瞻性观察性研究调查了口服西洛他唑对糖尿病视网膜病变的影响。在给药1周前后，分别使用搏动性眼血流（POBF）分析仪和经颅多普勒成像测量搏动性眼血流（POBF）和球后血流动力学。治疗前后还评估了视力、眼压和血压。

结果

本研究纳入了25例患者的25只眼。服用西洛他唑后，POBF显著增加（16.8±4.6µL/秒对19.6±6.2µL/秒，<0.001），而视力、眼压和血压无显著变化。经颅多普勒成像测量的眼动脉平均流速在用药后也显著增加（23.5±5.6厘米/秒对26.0±6.9厘米/秒，=0.001）。POBF的变化与平均流速的变化直接相关（r=0.419，=0.007）。