糖尿病视网膜病变中的搏动性眼血流

Pulsatile ocular blood flow in diabetic retinopathy.

作者信息

Geyer O, Neudorfer M, Snir T, Goldstein M, Rock T, Silver D M, Bartov E

机构信息

Department of Ophthalmology, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Israel.

出版信息

Acta Ophthalmol Scand. 1999 Oct;77(5):522-5. doi: 10.1034/j.1600-0420.1999.770507.x.

DOI:10.1034/j.1600-0420.1999.770507.x

PMID:10551292

Abstract

PURPOSE

To assess circulatory properties of eyes with progressive stages of diabetic retinopathy.

METHODS

The intraocular pressure, pulse amplitude (PA) and pulsatile ocular blood flow (POBF) were measured with a pneumatonometer (OBF Labs UK Ltd). The eyes were grouped: (a) normal control, n = 26, (b) diabetes with no observable diabetic retinopathy (NDR), n = 18, (c) mild to moderate non-proliferative diabetic retinopathy (NPDR), n = 20, and (d) very severe pre-proliferative and proliferative diabetic retinopathy (PPDR/PDR), n = 12.

RESULTS

The PA and POBF values were lower than normal values in the earliest stage (NDR). The POBF increased but was still below normal levels at the NPDR stage, and then increased to an above normal level in the PPDR/PDR stage of diabetic retinopathy. The PA was at normal levels in these later two stages.

CONCLUSION

An initial decrease in pulsatile ocular blood flow is present with the onset of diabetes where no diabetic retinopathy has yet occurred. Subsequently, the pulsatile ocular blood flow increases with the severity of the retinopathy.

摘要

目的

评估不同进展阶段糖尿病视网膜病变患者眼睛的循环特性。

方法

使用气压眼压计（英国OBF实验室有限公司）测量眼压、脉搏幅度（PA）和搏动性眼血流量（POBF）。将眼睛分为以下几组：（a）正常对照组，n = 26；（b）无明显糖尿病视网膜病变（NDR）的糖尿病患者，n = 18；（c）轻度至中度非增殖性糖尿病视网膜病变（NPDR），n = 20；（d）非常严重的增殖前期和增殖性糖尿病视网膜病变（PPDR/PDR），n = 12。