Erum Uzma, Ahsan Tasnim, Khowaja Danish
Dr. Uzma Erum, MBBS, FCPS Trainee. Medical Unit-II, Rafiqee Shaheed Road, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
Prof. Tasnim Ahsan, MRCP, FRCP, FRCP, FRCP. Medical Unit-II, Rafiqee Shaheed Road, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
Pak J Med Sci. 2017 Jan-Feb;33(1):227-230. doi: 10.12669/pjms.331.11699.
To determine the frequency of dyslipidemia in patients with Rheumatoid Arthritis.
This is a prospective, cross-sectional, observational study, conducted at the 'Rheumatology Clinic' of Jinnah Postgraduate Medical Center (JPMC), Karachi, from November 2013 to May 2014. A total of 200 patients of Rheumatoid Arthritis (RA), diagnosed according to the ACR/EULAR criteria 2010, were included in the study. Laboratory investigations including creatinine, ALT, CBC, TSH and fasting lipid profile (LDL, HDL, and Total cholesterol) were done for all patients.
Out of 200 patients, 23 (11.5%) were male and 177 (88.5%) were female. The mean age was 36.31±10.46 years and the mean duration of disease was 3.82±3.03 years. A total of 107 (53.5%) patients had dyslipidemia, and the commonest abnormality was a low HDL, seen in 83 (41.5 %) patients.
Dyslipidemia was frequently observed in Rheumatoid Arthritis. This may be considered as a secondary impact of chronic inflammatory state, seen in RA. Lipid abnormalities should be sought at regular intervals, and corrective actions taken to mitigate increased cardiovascular disease risk.
确定类风湿关节炎患者血脂异常的发生率。
这是一项前瞻性、横断面观察性研究，于2013年11月至2014年5月在卡拉奇真纳研究生医学中心（JPMC）的“风湿病诊所”进行。根据2010年美国风湿病学会（ACR）/欧洲抗风湿病联盟（EULAR）标准诊断的200例类风湿关节炎（RA）患者纳入研究。对所有患者进行了包括肌酐、谷丙转氨酶、全血细胞计数、促甲状腺激素和空腹血脂谱（低密度脂蛋白、高密度脂蛋白和总胆固醇）在内的实验室检查。
200例患者中，男性23例（11.5%），女性177例（88.5%）。平均年龄为36.31±10.46岁，平均病程为3.82±3.03年。共有107例（53.5%）患者存在血脂异常，最常见的异常是高密度脂蛋白降低，见于83例（41.5%）患者。
类风湿关节炎患者经常出现血脂异常。这可能被视为类风湿关节炎中慢性炎症状态的继发性影响。应定期检查血脂异常情况，并采取纠正措施以降低心血管疾病风险增加的情况。
