Nocera Joe, Crosson Bruce, Mammino Kevin, McGregor Keith M
VA Rehabilitation R&D Center for Visual and Neurocognitive Rehabilitation, Atlanta VAMC, Decatur, GA, USA; Department of Neurology, Emory University, Atlanta, GA, USA.
VA Rehabilitation R&D Center for Visual and Neurocognitive Rehabilitation, Atlanta VAMC, Decatur, GA, USA.
Neural Plast. 2017;2017:6340302. doi: 10.1155/2017/6340302. Epub 2017 Mar 6.
Previous work has shown that older adults who evidence increased right inferior frontal gyrus (IFG) activity during language tasks show decreased sematic verbal fluency performance. The current study sought to evaluate if an aerobic exercise intervention can alter patterns of brain activity during a semantic verbal fluency task assessed by functional magnetic resonance imaging (fMRI). Thirty-two community-dwelling, sedentary older adults were enrolled to a 12-week aerobic "Spin" exercise group or a 12-week nonaerobic exercise control condition (Balance). Thirty participants completed their assigned intervention (16 Spin; 14 Balance) with pre- and postintervention assessments of a semantic verbal fluency task during fMRI and estimated VOmax testing. There was a significant increase in the change scores for estimated VOmax of the Spin group when compared to the Balance group. Semantic verbal fluency output within the scanner was also improved in the Spin group as compared to controls at postassessment. Group fMRI comparisons of IFG activity showed lower activity in the right IFG following the intervention in the aerobic Spin group when compared to the Balance group. Regression analysis of imaging data with change in both estimated VOmax and semantic verbal fluency was negatively correlated with activity in right IFG. The current work is registered as clinical trial with NCT01787292 and NCT02787655.
先前的研究表明，在语言任务中右额下回（IFG）活动增强的老年人语义言语流畅性表现会下降。本研究旨在评估有氧运动干预是否能改变通过功能磁共振成像（fMRI）评估的语义言语流畅性任务期间的大脑活动模式。32名居住在社区、久坐不动的老年人被纳入一个为期12周的有氧“动感单车”运动组或一个为期12周的非有氧运动对照组（平衡训练）。30名参与者完成了他们被分配的干预（16名动感单车组；14名平衡训练组），并在fMRI期间对语义言语流畅性任务进行了干预前后的评估以及最大摄氧量测试。与平衡训练组相比，动感单车组的最大摄氧量变化得分有显著增加。与对照组相比，动感单车组在扫描过程中的语义言语流畅性输出在评估后也有所改善。对IFG活动的组间fMRI比较显示，与平衡训练组相比，有氧动感单车组在干预后右IFG的活动较低。对最大摄氧量和语义言语流畅性变化的成像数据进行回归分析，结果与右IFG的活动呈负相关。本研究已注册为临床试验，注册号为NCT01787292和NCT02787655。
