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一种用于测试支气管扩张剂的新型系统。

A Novel System to Test Bronchodilators.

作者信息

Addison Kenneth J, Morse John, Robichaud Annette, Daines Michael O, Ledford Julie G

机构信息

Department of Medicine, University of Arizona, Tucson, Arizona, USA.

SCIREQ Inc., Montreal, Québec, Canada.

出版信息

J Infect Pulm Dis. 2017 Mar;3(1). doi: 10.16966/2470-3176.120. Epub 2017 Feb 3.

DOI:10.16966/2470-3176.120
PMID:28367537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5375107/
Abstract

The incidence and severity of asthma continue to rise worldwide. β-agonists are the most commonly prescribed therapeutic for asthma management but have less efficacy for some subsets of asthmatic patients and there are concerns surrounding the side effects from their long-term persistent use. The demand to develop novel asthma therapeutics highlights the need for a standardized approach to effectively screen and test potential bronchoprotective compounds using relevant animal models. Here we describe a validated method of testing potential therapeutic compounds for their fast-acting efficacy during the midst of an induced bronchoconstriction in a house dust mite challenged animal model.

摘要

全球范围内，哮喘的发病率和严重程度持续上升。β-受体激动剂是哮喘治疗中最常用的药物，但对某些哮喘患者亚组疗效较差，且长期持续使用会产生副作用，令人担忧。开发新型哮喘治疗药物的需求凸显了采用标准化方法，利用相关动物模型有效筛选和测试潜在支气管保护化合物的必要性。在此，我们描述了一种经过验证的方法，用于在屋尘螨激发的动物模型中，测试潜在治疗化合物在诱发支气管收缩过程中的速效疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7fd/5375107/dbe2022a39b8/nihms850671f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7fd/5375107/6172e8b4fadf/nihms850671f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7fd/5375107/dbe2022a39b8/nihms850671f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7fd/5375107/6172e8b4fadf/nihms850671f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7fd/5375107/dbe2022a39b8/nihms850671f2.jpg

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Biol Open. 2016 Jan 6;5(2):112-21. doi: 10.1242/bio.014464.
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Postnatal overnutrition in mice leads to impaired pulmonary mechanics in response to salbutamol.小鼠出生后营养过剩会导致对沙丁胺醇的肺力学反应受损。
J Physiol Sci. 2016 May;66(3):221-8. doi: 10.1007/s12576-015-0417-0. Epub 2015 Oct 23.
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Repeated β2-adrenergic receptor agonist therapy attenuates the response to rescue bronchodilation in a hyperoxic newborn mouse model.
Am J Respir Cell Mol Biol. 2022 Nov;67(5):605-609. doi: 10.1165/rcmb.2022-0181LE.
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Creatine Kinase Is Decreased in Childhood Asthma.肌酸激酶在儿童哮喘中降低。
Am J Respir Crit Care Med. 2023 Mar 1;207(5):544-552. doi: 10.1164/rccm.202010-3746OC.
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Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells.糖识别结构域内的小肽衍生物调节 SP-A2 在小鼠模型和人细胞中的哮喘结局。
Front Immunol. 2022 Jul 8;13:900022. doi: 10.3389/fimmu.2022.900022. eCollection 2022.
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Br J Pharmacol. 2023 Mar;180(5):667-680. doi: 10.1111/bph.15903. Epub 2022 Dec 5.
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