Oh Jae Gyun, Ishikawa Kiyotake
Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Methods Mol Biol. 2018;1816:3-14. doi: 10.1007/978-1-4939-8597-5_1.
Cardiovascular disease is one of the most common causes of deaths in clinics. Experimental models of cardiovascular diseases are essential to understand disease mechanism, to provide accurate diagnoses, and to develop new therapies. Large numbers of experimental models have been proposed and replicated by many laboratories in the past. Models with significant advantages are chosen and became more popular. Particularly, feasibility, reproducibility, and human disease resemblance are the common key factors for frequently used cardiovascular disease models. In this chapter, we provide a brief overview of these experimental models used for in vitro, in vivo, and in silico studies of cardiovascular diseases.
心血管疾病是临床上最常见的死亡原因之一。心血管疾病的实验模型对于理解疾病机制、提供准确诊断以及开发新疗法至关重要。过去，许多实验室已经提出并复制了大量的实验模型。具有显著优势的模型被挑选出来并变得更加流行。特别是，可行性、可重复性和与人类疾病的相似性是常用心血管疾病模型的共同关键因素。在本章中，我们简要概述了用于心血管疾病体外、体内和计算机模拟研究的这些实验模型。
