Landauer M R, Davis H D, Dominitz J A, Weiss J F
Department of Behavioral Sciences, Armed Forces Radiobiology Research Institute, Bethesda, MD 20814-5145.
Toxicology. 1988 May;49(2-3):315-23. doi: 10.1016/0300-483x(88)90014-5.
The effects of 13 Gy gamma-radiation alone and in combination with 200 mg/kg of the radioprotector S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) on locomotor activity and body weight were examined in CD2F1 mice over a 10-month period. The results confirmed that WR-2721 is an excellent radioprotector against lethality. All mice receiving 13 Gy without WR-2721 died in 5-7 days. For mice that received WR-2721 alone or WR-2721 + radiation, survival at 30 days was 100% and 70%, respectively. Body weights of mice receiving WR-2721 without radiation were comparable to control animals. Body weights of animals given WR-2721 + radiation fell on days 1-5 and then increased until day 11, but remained below control values throughout the experiment. Animals in the radiation-only group did not exhibit any significant reductions in behavior until day 2 post-irradiation. Mice administered WR-2721 alone showed significantly reduced locomotor activity levels on day 0 then completely recovered within 24 h and exhibited normal body weights. Animals given WR-2721 before irradiation showed greater reductions in locomotor activity on day 0 than either the WR-2721 or radiation-only groups and recovered to control level by day 3. Beginning on day 5, they showed significant reductions in activity. Mice pretreated with WR-2721 that survived a normally lethal dose of radiation showed a 20-40% reduction in locomotor performance that recovered in 2-5 months.
在10个月的时间里，研究了13 Gy的γ射线单独照射以及与200 mg/kg辐射防护剂S-2-(3-氨丙基氨基)乙基硫代磷酸(WR-2721)联合照射对CD2F1小鼠运动活性和体重的影响。结果证实，WR-2721是一种出色的抗致死性辐射防护剂。所有接受13 Gy照射且未使用WR-2721的小鼠在5 - 7天内死亡。单独接受WR-2721或接受WR-2721 +辐射的小鼠，30天时的存活率分别为100%和70%。未接受辐射仅接受WR-2721的小鼠体重与对照动物相当。接受WR-2721 +辐射的动物体重在第1 - 5天下降，然后在第11天前增加，但在整个实验过程中一直低于对照值。仅接受辐射的组在照射后第2天才出现行为上的显著减少。单独给予WR-2721的小鼠在第0天运动活性水平显著降低，然后在24小时内完全恢复，体重正常。照射前给予WR-2721的动物在第0天的运动活性降低幅度大于单独使用WR-2721组或仅接受辐射组，并在第3天恢复到对照水平。从第5天开始，它们的活性显著降低。用WR-2721预处理并在正常致死剂量辐射下存活的小鼠，运动能力降低了20 - 40%，并在2 - 5个月内恢复。
