对实验感染盖塔病毒的猪的临床和病毒学观察。

Clinical and virological observations on swine experimentally infected with Getah virus.

作者信息

Kumanomido T, Wada R, Kanemaru T, Kamada M, Hirasawa K, Akiyama Y

机构信息

Equine Research Institute, Japan Racing Association, Tochigi.

出版信息

Vet Microbiol. 1988 Mar;16(3):295-301. doi: 10.1016/0378-1135(88)90033-8.

DOI:10.1016/0378-1135(88)90033-8

PMID:2836997

Abstract

The pathogenicity of Getah virus for swine was examined. All 8 pigs (4 adults and 4 piglets) inoculated with Strains MIP-99 and MI-110 developed pyrexia ranging from 39.4 to 40.7 degrees C and anorexia. Mild depression and diarrhea were observed in 2 of the 4 piglets. These clinical signs were transient. Viremia occurred 1-2 days post-inoculation (p.i.) and the maximum titer was 10(3.0) TCID50 0.1 ml-1. The virus was recovered from a piglet autopsied on Day 3 p.i. from spleen and various lymph nodes. The maximum titer of virus (10(3.75) TCID50 0.1 g-1) was detected in the inguinal lymph node. Seroconversion was demonstrated in all the pigs on Day 6 p.i. These results suggest that Getah virus is mildly pathogenic for swine, which may play a role as an amplifying host in nature.

摘要

对盖塔病毒对猪的致病性进行了检测。接种MIP - 99株和MI - 110株的所有8头猪（4头成年猪和4头仔猪）均出现了39.4至40.7摄氏度的发热及厌食症状。4头仔猪中有2头出现轻度抑郁和腹泻。这些临床症状是短暂的。接种后1 - 2天出现病毒血症，最高滴度为10(3.0) TCID50 0.1 ml-1。在接种后第3天剖检的一头仔猪的脾脏和各种淋巴结中分离到了病毒。在腹股沟淋巴结中检测到病毒的最高滴度（10(3.75) TCID50 0.1 g-1）。所有猪在接种后第6天出现血清学转换。这些结果表明，盖塔病毒对猪具有轻度致病性，猪在自然环境中可能作为扩增宿主发挥作用。