Smith T, Jakobsen J, Gaub J, Helweg-Larsen S, Trojaborg W
Department of Clinical Neurophysiology NF, Rigshospitalet, Copenhagen, Denmark.
Ann Neurol. 1988 Mar;23(3):295-7. doi: 10.1002/ana.410230313.
Motor weakness and ataxia of lower limbs and abnormalities of somatosensory evoked potentials occur in many patients with the acquired immunodeficiency syndrome (AIDS). We studied 15 human immunodeficiency virus-seropositive subjects without AIDS and found no clinical neurological abnormalities. The mean latency of the brainstem auditory evoked potential (peak V) was increased, suggesting a central defect. Despite normal peripheral nerve conduction along the tibial nerve, the mean latency of the spinal cord potential of the twelfth thoracic vertebra was increased compared with normal, possibly indicating an incipient conduction defect at or near the spinal root ganglion or lumbar spinal cord.
许多获得性免疫缺陷综合征（AIDS）患者会出现下肢运动无力、共济失调以及体感诱发电位异常。我们研究了15名未患AIDS的人类免疫缺陷病毒血清阳性受试者，未发现临床神经学异常。脑干听觉诱发电位（V波峰）的平均潜伏期延长，提示存在中枢缺陷。尽管沿胫神经的周围神经传导正常，但第十二胸椎脊髓电位的平均潜伏期与正常相比延长，这可能表明在脊神经根神经节或腰脊髓处或其附近存在早期传导缺陷。
