Helweg-Larsen S, Jakobsen J, Boesen F, Arlien-Søborg P, Brun B, Smith T, Ulrich K, Orskov B, Gyldensted C, Permin H
National Hospital, Copenhagen, Denmark.
Acta Neurol Scand. 1988 Jan;77(1):64-73. doi: 10.1111/j.1600-0404.1988.tb06976.x.
In a cross-sectional population study of Danish patients with AIDS 16 of 23 had clinical signs of neurological disease with muscle weakness or ataxia of the lower limbs as the dominant manifestation. Tibial and median nerve conduction was mildly slowed in a few patients and 15 had widening of cerebral ventricles at CT. However, all had prolonged latency of cortical evoked response following tibial nerve stimulation mainly due to slowing through the spinal cord. The prolongation of the latency of the evoked cortical responses was most pronounced in patients with lower limb ataxia and/or paresis. It is concluded that affection of the long tracts of the spinal cord are closely associated with the human immunodeficiency virus infection.
在一项针对丹麦艾滋病患者的横断面人群研究中，23名患者中有16名出现神经疾病的临床症状，以下肢肌肉无力或共济失调为主要表现。少数患者胫神经和正中神经传导略有减慢，15名患者在CT检查时出现脑室扩大。然而，所有患者在胫神经刺激后皮质诱发反应的潜伏期均延长，主要是由于脊髓传导减慢。诱发皮质反应潜伏期的延长在下肢共济失调和/或轻瘫患者中最为明显。结论是脊髓长束受累与人类免疫缺陷病毒感染密切相关。
