Tam Y C, Chopra A, Hassan M, Thirion J P
Department of Microbiology, Faculty of Medicine Centre Hospitalier Universitaire, Sherbrooke, Quebec, Canada.
Biochem Biophys Res Commun. 1988 May 31;153(1):209-16. doi: 10.1016/s0006-291x(88)81210-5.
We have isolated a rabbit metallothionein-I gene from a lambda gt10 library. The coding sequence of this gene is interrupted by two introns occurring at amino acid positions 9 1/3 and 30 1/3. Comparison of the promoter sequence of this gene with the promoters of other metallothionein genes identified a number of oligonucleotide sequences which are recognized by trans-acting proteins involved in the regulation of these genes by heavy metals, glucocorticoids and alpha interferon.
