Liu Lihong, Liu Aifeng, Zhang Qinghua, Shi Jianbo, He Bin, Yun Zhaojun, Jiang Guibin
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China.
CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
J Chromatogr A. 2017 May 12;1497:81-86. doi: 10.1016/j.chroma.2017.03.040. Epub 2017 Mar 19.
As the most widely used brominated flame retardants (BFRs), Tetrabromobisphenol-A (TBBPA) as well as its alternative Tetrabromobisphenol-S (TBBPS) and their derivatives have raised wide concerns due to their adverse effects on human health and hence the sensitive detection of those BFRs was urgently needed. Herein, a novel analytical method based on high-performance liquid chromatography (HPLC) coupled with inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) has been developed for the determination of TBBPA/S and their derivatives, including TBBPA-bis(2-hydroxyethyl ether) (TBBPA-BHEE), TBBPA-bis(allylether) (TBBPA-BAE), TBBPA-bis(glycidyl ether) (TBBPA-BGE), TBBPA-bis(2,3-dibromopropyl ether) (TBBPA-BDBPE) and TBBPS-bis(2,3-dibromopropyl ether) (TBBPS-BDBPE) in water samples. After optimization, the TBBPA/S and their derivatives, especially the TBBPA-BAE and TBBPA-BDBPE were simultaneously and sensitively quantified by determination of bromine (m/z=79) by using the ICP-MS. The instrument limits of detection (LODs) for the TBBPA, TBBPA-BHEE, TBBPA-BGE, TBBPA-BAE, TBBPA-BDBPE, TBBPS and TBBPS-BDBPE were determined to be 0.12, 0.14, 0.19, 0.14, 0.12, 0.17 and 0.13μgL, respectively, which was close to or much better than the reported methods. The relative standard deviations (RSDs, n=5) of peak area and retention time were better than 2.2% and 0.2% for intra-day analysis, indicating good repeatability and high precision. The proposed method had been successfully applied for the analysis of TBBPA/S and their derivatives in water samples with satisfactory recoveries (67.7%-113%).
作为使用最广泛的溴化阻燃剂（BFRs），四溴双酚A（TBBPA）及其替代品四溴双酚S（TBBPS）及其衍生物因其对人体健康的不利影响而引起了广泛关注，因此迫切需要对这些溴化阻燃剂进行灵敏检测。在此，开发了一种基于高效液相色谱（HPLC）与电感耦合等离子体串联质谱（ICP-MS/MS）联用的新型分析方法，用于测定水样中的TBBPA/S及其衍生物，包括四溴双酚A-双（2-羟乙基醚）（TBBPA-BHEE）、四溴双酚A-双（烯丙基醚）（TBBPA-BAE）、四溴双酚A-双（缩水甘油醚）（TBBPA-BGE）、四溴双酚A-双（2,3-二溴丙基醚）（TBBPA-BDBPE）和四溴双酚S-双（2,3-二溴丙基醚）（TBBPS-BDBPE）。经过优化，通过电感耦合等离子体质谱法测定溴（m/z=79），可同时灵敏地定量测定TBBPA/S及其衍生物，尤其是TBBPA-BAE和TBBPA-BDBPE。TBBPA、TBBPA-BHEE、TBBPA-BGE、TBBPA-BAE、TBBPA-BDBPE、TBBPS和TBBPS-BDBPE的仪器检测限分别确定为0.12、0.14、0.19、0.14、0.12、0.17和0.13μg/L，接近或优于已报道的方法。日内分析中，峰面积和保留时间的相对标准偏差（RSDs，n=5）优于2.2%和0.2%，表明重复性好、精密度高。该方法已成功应用于水样中TBBPA/S及其衍生物的分析，回收率令人满意（67.7%-113%）。
