Kenangil Gülay, Özdilek Betül
Clinic of Neurology, Erenköy Research and Training Hospital for Neurologic and Psychiatric Disorders, İstanbul, Turkey.
Noro Psikiyatr Ars. 2016 Sep;53(3):241-244. doi: 10.5152/npa.2016.11319. Epub 2016 Sep 1.
To investigate the relationship between serum leptin levels and cognition in Parkinson's disease (PD) patients.
Thirty patients with idiopathic PD and 30 healthy controls were enrolled. At baseline, all patients had their standing height, weight, and waist circumference measurements taken using a standard scale. Their body mass index was then calculated. A fasting blood of 5 ml was obtained from each patient in the morning. ELISA was used to analyze leptin concentrations. The severity of PD was evaluated using the Hoehn and Yahr scale, and the clinical status of patients was evaluated using the Unified Parkinson's Disease Rating Scale. The cognitive status of whole patients was evaluated using a validated form of the Montreal Cognitive Assessment Scale in Turkey (MoCA-TR).
The mean ages of the patients and controls were 59.37±9.22 and 58.50±9.85 years, while the mean leptin levels were 4.13±3.61 and 3.12±2.43 ng/mL, respectively. Leptin levels did not differ between PD patients and the controls. PD patients had significantly lower MoCA-TR scores than the controls (p=0.028). MoCA-TR scores were not correlated to leptin levels in PD patients.
In this study, we could not find a relationship between blood leptin levels of PD patients and cognition as assessed by MoCA-TR. Larger longitudinal studies are needed.
探讨帕金森病（PD）患者血清瘦素水平与认知功能之间的关系。
招募30例特发性PD患者和30名健康对照者。在基线时，所有患者均使用标准秤测量身高、体重和腰围，然后计算其体重指数。每天早晨从每位患者采集5ml空腹血样，采用酶联免疫吸附测定法（ELISA）分析瘦素浓度。使用Hoehn和Yahr量表评估PD的严重程度，使用统一帕金森病评定量表评估患者的临床状态。使用经过验证的土耳其版蒙特利尔认知评估量表（MoCA-TR）评估所有患者的认知状态。
患者和对照组的平均年龄分别为59.37±9.22岁和58.50±9.85岁，平均瘦素水平分别为4.13±3.61 ng/mL和3.12±2.43 ng/mL。PD患者和对照组的瘦素水平无差异。PD患者的MoCA-TR评分显著低于对照组（p=0.028）。PD患者的MoCA-TR评分与瘦素水平无相关性。
在本研究中，我们未发现PD患者血液瘦素水平与MoCA-TR评估的认知功能之间存在关联。需要开展更大规模的纵向研究。
