帕金森病患者循环中脑源性神经营养因子与认知缺陷的关系。
Relationship of circulatory BDNF with cognitive deficits in people with Parkinson's disease.
作者信息
Khalil Hanan, Alomari Mahmoud A, Khabour Omar F, Al-Hieshan Aya, Bajwa Jawad A
机构信息
Jordan University of Science and Technology, Faculty of Applied Medical Sciences, Department of Rehabilitation Sciences, Irbid, Jordan.
Jordan University of Science and Technology, Division of Physical Therapy, Department of Rehabilitation Sciences, Irbid, Jordan.
出版信息
J Neurol Sci. 2016 Mar 15;362:217-20. doi: 10.1016/j.jns.2016.01.032. Epub 2016 Jan 21.
BACKGROUND
Brain-derived neurotrophic factor (BDNF) and cognitive function are diminished in people with Parkinson's disease (PD). The relationship of cognitive function and serum level of BDNF, however is yet to be examined. The aim of this study was to examine serum BDNF levels in PD. Subsequently, the relationship of cognitive function to the serum levels of BDNF was evaluated.
METHODS
Serum BDNF levels were measured in 29 idiopathic PD subjects and 30 healthy-matched controls using ELISA technique. Cognitive function was assessed using the Montreal Cognitive Assessment (MOCA) scale.
RESULTS
Serum BDNF levels and MOCA total score were significantly lower (P<0.001) in PD patients versus healthy controls. MOCA total score correlated with serum BDNF (r=0.44; P=0.012) but not with age, years of education, duration of disease and severity of symptoms. The regression analysis showed that serum BDNF accounted (P=0.019) for 19% of MOCA total score variance.
CONCLUSIONS
The data confirm lowered serum BDNF in PD. Additionally; it suggests that BDNF may play a role in the cognitive deficit of PD. Further studies are required to identify association of BDNF in cognitive decline with PD.
背景
帕金森病（PD）患者脑源性神经营养因子（BDNF）和认知功能会降低。然而，认知功能与血清BDNF水平之间的关系尚未得到研究。本研究的目的是检测帕金森病患者的血清BDNF水平。随后，评估认知功能与血清BDNF水平之间的关系。
方法
采用酶联免疫吸附测定（ELISA）技术，对29例特发性帕金森病患者和30例健康对照者进行血清BDNF水平检测。使用蒙特利尔认知评估量表（MOCA）评估认知功能。
结果
与健康对照组相比，帕金森病患者的血清BDNF水平和MOCA总分显著降低（P<0.001）。MOCA总分与血清BDNF相关（r=0.44；P=0.012），但与年龄、受教育年限、病程和症状严重程度无关。回归分析显示，血清BDNF占MOCA总分变异的19%（P=0.019）。
结论
数据证实帕金森病患者血清BDNF降低。此外，这表明BDNF可能在帕金森病的认知缺陷中起作用。需要进一步研究以确定BDNF与帕金森病认知衰退之间的关联。
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