Shah Syed Niaz Ali, Shah Zahir, Hussain Muzammal, Khan Muzaffar
Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan; Department of Chemistry, Tsinghua University, Beijing 100084, China.
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, China; Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Bioinorg Chem Appl. 2017;2017:4101735. doi: 10.1155/2017/4101735. Epub 2017 Mar 8.
Although nanoparticles (NPs) have made incredible progress in the field of nanotechnology and biomedical research and their applications are demanded throughout industrial world particularly over the past decades, little is known about the fate of nanoparticles in ecosystem. Concerning the biosafety of nanotechnology, nanotoxicity is going to be the second most priority of nanotechnology that needs to be properly addressed. This review covers the chemical as well as the biological concerns about nanoparticles particularly titanium dioxide (TiO) NPs and emphasizes the toxicological profile of TiO at the molecular level in both in vitro and in vivo systems. In addition, the challenges and future prospects of nanotoxicology are discussed that may provide better understanding and new insights into ongoing and future research in this field.
尽管纳米颗粒（NPs）在纳米技术和生物医学研究领域取得了惊人的进展，并且在整个工业界都有需求，尤其是在过去几十年中，但人们对纳米颗粒在生态系统中的命运知之甚少。关于纳米技术的生物安全性，纳米毒性将成为纳米技术的第二大优先事项，需要妥善解决。本综述涵盖了关于纳米颗粒特别是二氧化钛（TiO₂）纳米颗粒的化学和生物学问题，并强调了TiO₂在体外和体内系统中分子水平的毒理学特征。此外，还讨论了纳米毒理学的挑战和未来前景，这可能为该领域正在进行的和未来的研究提供更好的理解和新的见解。
