Osifo B O, Ayoola A, Parmentier Y, Gerard P, Nicolas J P
Laboratory of Medical Biochemistry, Inserm U 308, Faculty of Medicine, University of Nancy, Vandoeuvre-Les-Nancy, France.
Enzyme. 1988;39(3):161-6. doi: 10.1159/000469112.
The serum unsaturated vitamin B12-binding capacity (UBBC), unsaturated transcobalamin (UTC) I, UTC II, UTC III levels, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase activities and bilirubin concentration were estimated in 61 patients with liver diseases (31 with hepatoma, 30 with viral hepatitis). The levels of serum cobalamin, UTC I, UTC III, UBBC, alanine and aspartate aminotransferases, and bilirubin were raised in both hepatoma and viral hepatitis patients. Serum UTC II was reduced in both conditions. Alkaline phosphatase activity was significantly increased in hepatoma. Four significant correlations were observed among these parameters in the hepatoma patients while only one significant correlation was observed in viral hepatitis.
对61例肝病患者（31例肝癌患者，30例病毒性肝炎患者）的血清不饱和维生素B12结合能力（UBBC）、不饱和转钴胺素（UTC）I、UTC II、UTC III水平、丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶活性及胆红素浓度进行了测定。肝癌患者和病毒性肝炎患者的血清钴胺素、UTC I、UTC III、UBBC、丙氨酸和天冬氨酸转氨酶及胆红素水平均升高。两种情况下血清UTC II均降低。肝癌患者碱性磷酸酶活性显著升高。肝癌患者的这些参数之间观察到4个显著相关性，而病毒性肝炎患者仅观察到1个显著相关性。
