Ding Wengang, Li Wanying, Zeng Xianzhang, Li Jinying, Jiang Jingjing, Guo Changchun, Li Wenzhi
Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, 246, Xuefu Road, Harbin, Heilongjiang, 150086, China.
J Gastrointest Surg. 2017 Jun;21(6):936-946. doi: 10.1007/s11605-017-3402-5. Epub 2017 Apr 3.
Transversus abdominis plane (TAP) block is an analgesic technique. Adding dexmedetomidine can enhance regional anesthesia. This study's aim was to evaluate whether dexmedetomidine prolonged analgesic time of TAP block after gastrectomy.
Patients scheduled for gastrectomy were randomly assigned to receive a TAP block with saline (group S), ropivacaine (group R), or ropivacaine and dexmedetomidine (group RD). Visual analogue scale (VAS) scores, postoperative nausea and vomiting (PONV) scores, sedation scores, tramadol consumption, ropivacaine concentration, and Quality of Recovery Questionnaire 40 (QoR-40) were recorded.
Patients in group R and group RD had lower VAS scores 2, 4, 12, and 24 h after surgery compared with group S (P < 0.05). PONV scores were lower in group R and group RD compared with group S after 2, 12, 24, and 36 h (P < 0.05). Patients in group R and group RD required less tramadol and had better QoR-40 scores than those in group S (P < 0.05). The aforementioned variables and ropivacaine concentrations did not differ between group R and group RD (P > 0.05). Sedation scores were similar between three groups (P > 0.05).
TAP block can provide analgesia and improve the quality of recovery. Adding dexmedetomidine does not significantly improve the quality or duration of TAP block.
腹横肌平面(TAP)阻滞是一种镇痛技术。添加右美托咪定可增强区域麻醉效果。本研究旨在评估右美托咪定是否能延长胃癌切除术后TAP阻滞的镇痛时间。
计划行胃癌切除术的患者被随机分配接受生理盐水TAP阻滞(S组)、罗哌卡因TAP阻滞(R组)或罗哌卡因联合右美托咪定TAP阻滞(RD组)。记录视觉模拟评分(VAS)、术后恶心呕吐(PONV)评分、镇静评分、曲马多用量、罗哌卡因浓度及术后恢复质量问卷40(QoR-40)评分。
与S组相比,R组和RD组患者术后2、4、12和24小时的VAS评分更低(P<0.05)。术后2、12、24和36小时,R组和RD组的PONV评分低于S组(P<0.05)。与S组相比,R组和RD组患者所需曲马多更少,QoR-40评分更高(P<0.05)。R组和RD组之间上述变量及罗哌卡因浓度无差异(P>0.05)。三组镇静评分相似(P>0.05)。
TAP阻滞可提供镇痛并改善恢复质量。添加右美托咪定并不能显著改善TAP阻滞的质量或持续时间。