Lu Yanhui, An Yu, Yu Huanling, Che Fengyuan, Zhang Xiaona, Rong Hongguo, Xi Yuandi, Xiao Rong
School of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
Linyi Mental Health Center, Linyi, Shandong, China.
Metab Brain Dis. 2017 Aug;32(4):1089-1097. doi: 10.1007/s11011-017-9999-y. Epub 2017 Apr 3.
To examine how serum lipids relates to specific cognitive ability domains between the men and women in Chinese middle to older age individuals. A complete lipid panel was obtained from 1444 individuals, ages 50-65, who also underwent a selection of cognitive tests. Participants were 584 men and 860 women from Linyi city, Shandong province. Multiple linear regression analyses examined serum lipids level as quadratic predictors of sex-specific measure of performance in different cognitive domains, which were adjusted for sociodemographic and lifestyle characteristics. In men, a significant quadratic effect of total cholesterol (TC) was identified for Digit Symbol (B = -0.081, P = 0.044) and also quadratic effect of low density lipoprotein-cholesterol (LDL-C) was identified for Trail Making Test B (B = -0.082, P = 0.045). Differently in women, there were significant quadratic associations between high density lipoprotein-cholesterol (HDL-C) and multiple neuropsychological tests. The nonlinear lipid-cognition associations differed between men and women and were specific to certain cognitive domains and might be of potential relevance for prevention and therapy of cognitive decline.
为研究中国中老年人群中血清脂质与男性和女性特定认知能力领域之间的关系。从1444名年龄在50 - 65岁的个体中获取了完整的血脂指标，这些个体还接受了一系列认知测试。参与者来自山东省临沂市，其中男性584名，女性860名。多元线性回归分析将血清脂质水平作为不同认知领域中性别特异性表现指标的二次预测因子，并对社会人口统计学和生活方式特征进行了调整。在男性中，总胆固醇（TC）对数字符号测试有显著的二次效应（B = -0.081，P = 0.044），低密度脂蛋白胆固醇（LDL-C）对连线测验B也有二次效应（B = -0.082，P = 0.045）。在女性中，高密度脂蛋白胆固醇（HDL-C）与多项神经心理学测试之间存在显著的二次关联。脂质与认知的非线性关联在男性和女性之间存在差异，且特定于某些认知领域，可能对认知衰退的预防和治疗具有潜在意义。
