• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

免疫功能正常宿主发生严重腺病毒肺炎伴持续发热，因疑似细菌合并感染接受多种经验性抗生素治疗：抗生素管理中降阶梯治疗失败的案例分析

Severe Adenoviral Pneumonia in an Immunocompetent Host with Persistent Fevers Treated with Multiple Empiric Antibiotics for Presumed Bacterial Co-Infection: An Antibiotic Stewardship Perspective on De-Escalation Derailed.

作者信息

Cunha Burke A, Gian John, Klein Natalie C

机构信息

Infectious Disease Division, Winthrop-University Hospital, 222 Station Plaza North (Suite #432), Mineola, New York, NY 11501, USA.

School of Medicine, State University of New York, Stony Brook, New York, NY 11794, USA.

出版信息

J Clin Med. 2017 Apr 4;6(4):42. doi: 10.3390/jcm6040042.

DOI:10.3390/jcm6040042
PMID:28375168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5406774/
Abstract

We present a case of severe adenoviral pneumonia in a 20-year-old immunocompetent host with persistently high fevers. The patient was needlessly given multiple empiric antibiotics for non-existent bacterial co-infection. This case has important antibiotic stewardship lessons for practitioners in approaching fevers in the ICU.

摘要

我们报告一例20岁免疫功能正常的宿主发生的严重腺病毒肺炎，该患者持续高热。该患者因不存在的细菌合并感染而不必要地接受了多种经验性抗生素治疗。该病例为重症监护病房的从业者在处理发热问题时提供了重要的抗生素管理经验教训。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb62/5406774/74619933f3c5/jcm-06-00042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb62/5406774/74619933f3c5/jcm-06-00042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb62/5406774/74619933f3c5/jcm-06-00042-g001.jpg

相似文献

1
Severe Adenoviral Pneumonia in an Immunocompetent Host with Persistent Fevers Treated with Multiple Empiric Antibiotics for Presumed Bacterial Co-Infection: An Antibiotic Stewardship Perspective on De-Escalation Derailed.免疫功能正常宿主发生严重腺病毒肺炎伴持续发热，因疑似细菌合并感染接受多种经验性抗生素治疗：抗生素管理中降阶梯治疗失败的案例分析
J Clin Med. 2017 Apr 4;6(4):42. doi: 10.3390/jcm6040042.
2
Frequency of empiric antibiotic de-escalation in an acute care hospital with an established Antimicrobial Stewardship Program.在一家设有抗菌药物管理项目的急症医院中经验性抗生素降阶梯治疗的频率。
BMC Infect Dis. 2016 Dec 12;16(1):751. doi: 10.1186/s12879-016-2080-3.
3
Empiric broad-spectrum antibiotic therapy of nosocomial pneumonia in the intensive care unit: a prospective observational study.重症监护病房医院获得性肺炎的经验性广谱抗生素治疗：一项前瞻性观察研究。
Crit Care. 2006;10(3):R78. doi: 10.1186/cc4919. Epub 2006 May 16.
4
Enhanced antimicrobial de-escalation for pneumonia in mechanically ventilated patients: a cross-over study.机械通气患者肺炎的强化抗菌降阶梯治疗：一项交叉研究。
Crit Care. 2017 Jul 15;21(1):180. doi: 10.1186/s13054-017-1772-4.
5
Evaluation of empiric antibiotic de-escalation in febrile neutropenia.发热性中性粒细胞减少症经验性抗生素降阶梯治疗的评估
J Oncol Pharm Pract. 2016 Oct;22(5):696-701. doi: 10.1177/1078155215597558. Epub 2015 Jul 30.
6
Empiric, broad-spectrum antibiotic therapy with an aggressive de-escalation strategy does not induce gram-negative pathogen resistance in ventilator-associated pneumonia.经验性、广谱抗生素治疗联合积极降阶梯策略不会导致呼吸机相关性肺炎的革兰氏阴性病原体耐药。
Surg Infect (Larchmt). 2010 Oct;11(5):427-32. doi: 10.1089/sur.2009.046.
7
De-escalation therapy in ventilator-associated pneumonia.呼吸机相关性肺炎的降阶梯治疗
Curr Opin Crit Care. 2006 Oct;12(5):452-7. doi: 10.1097/01.ccx.0000244126.84989.a2.
8
A retrospective study of antibiotic de-escalation in patients with ventilator-associated pneumonia in Malaysia.马来西亚呼吸机相关性肺炎患者抗生素降阶梯治疗的回顾性研究。
Int J Clin Pharm. 2017 Aug;39(4):906-912. doi: 10.1007/s11096-017-0499-2. Epub 2017 Jun 22.
9
Impact of a Pharmacist-driven Methicillin-resistant Staphylococcus aureus Polymerase Chain Reaction Nasal Swab Protocol on the De-escalation of Empiric Vancomycin in Patients with Pneumonia in a Rural Healthcare Setting.在农村医疗环境中，药师主导的耐甲氧西林金黄色葡萄球菌聚合酶链反应鼻拭子检测方案对肺炎患者经验性万古霉素降阶梯治疗的影响。
Cureus. 2019 Dec 13;11(12):e6378. doi: 10.7759/cureus.6378.
10
Empiric Antibiotic Therapy for Severe Sepsis and Septic Shock.重症脓毒症和感染性休克的经验性抗生素治疗
Surg Infect (Larchmt). 2016 Apr;17(2):210-6. doi: 10.1089/sur.2014.096. Epub 2015 Dec 2.

引用本文的文献

1
Severe community acquired adenovirus pneumonia in an immunocompetent host successfully treated with IV Cidofovir.免疫功能正常宿主的重症社区获得性腺病毒肺炎经静脉注射西多福韦成功治愈。
Respir Med Case Rep. 2020 Mar 10;30:101037. doi: 10.1016/j.rmcr.2020.101037. eCollection 2020.

本文引用的文献

1
What is the role of antimicrobial stewardship in improving outcomes of patients with CAP?抗菌药物管理在改善 CAP 患者结局中的作用是什么？
Infect Dis Clin North Am. 2013 Mar;27(1):211-28. doi: 10.1016/j.idc.2012.11.008.
2
Adenovirus.腺病毒。
Semin Respir Crit Care Med. 2011 Aug;32(4):494-511. doi: 10.1055/s-0031-1283287. Epub 2011 Aug 19.
3
Viral infection in adults hospitalized with community-acquired pneumonia: prevalence, pathogens, and presentation.社区获得性肺炎成人住院患者的病毒感染：患病率、病原体及临床表现
Chest. 2008 Dec;134(6):1141-1148. doi: 10.1378/chest.08-0888. Epub 2008 Aug 8.
4
Comparison between pathogen directed antibiotic treatment and empirical broad spectrum antibiotic treatment in patients with community acquired pneumonia: a prospective randomised study.社区获得性肺炎患者中病原体导向性抗生素治疗与经验性广谱抗生素治疗的比较：一项前瞻性随机研究。
Thorax. 2005 Aug;60(8):672-8. doi: 10.1136/thx.2004.030411.
5
Fever in the intensive care unit.
Intensive Care Med. 1999 Jul;25(7):648-51. doi: 10.1007/s001340050925.
6
Fever in the critical care unit.重症监护病房中的发热
Crit Care Clin. 1998 Jan;14(1):1-14. doi: 10.1016/s0749-0704(05)70378-x.
7
Treatment of fever.发热的治疗。
Infect Dis Clin North Am. 1996 Mar;10(1):211-6. doi: 10.1016/s0891-5520(05)70295-6.
8
Fever in the intensive care unit.重症监护病房中的发热
Infect Dis Clin North Am. 1996 Mar;10(1):185-209. doi: 10.1016/s0891-5520(05)70294-4.
9
Intensive care, not intensive antibiotics.重症监护，而非强化使用抗生素。
Heart Lung. 1994 Sep-Oct;23(5):361-2.