Mueller F, Lenz C, Dolder P C, Harder S, Schmid Y, Lang U E, Liechti M E, Borgwardt S
Department of Psychiatry, Universitäre Psychiatrische Kliniken, University of Basel, Basel, Switzerland.
Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
Transl Psychiatry. 2017 Apr 4;7(4):e1084. doi: 10.1038/tp.2017.54.
Lysergic acid diethylamide (LSD) induces profound changes in various mental domains, including perception, self-awareness and emotions. We used functional magnetic resonance imaging (fMRI) to investigate the acute effects of LSD on the neural substrate of emotional processing in humans. Using a double-blind, randomised, cross-over study design, placebo or 100 μg LSD were orally administered to 20 healthy subjects before the fMRI scan, taking into account the subjective and pharmacological peak effects of LSD. The plasma levels of LSD were determined immediately before and after the scan. The study (including the a priori-defined study end point) was registered at ClinicalTrials.gov before study start (NCT02308969). The administration of LSD reduced reactivity of the left amygdala and the right medial prefrontal cortex relative to placebo during the presentation of fearful faces (P<0.05, family-wise error). Notably, there was a significant negative correlation between LSD-induced amygdala response to fearful stimuli and the LSD-induced subjective drug effects (P<0.05). These data suggest that acute administration of LSD modulates the engagement of brain regions that mediate emotional processing.
麦角酸二乙酰胺（LSD）会在包括感知、自我意识和情绪在内的各个心理领域引发深刻变化。我们使用功能磁共振成像（fMRI）来研究LSD对人类情绪加工神经基质的急性影响。采用双盲、随机、交叉研究设计，在fMRI扫描前，给20名健康受试者口服安慰剂或100μg LSD，并考虑到LSD的主观和药理学峰值效应。在扫描前后立即测定LSD的血浆水平。该研究（包括预先定义的研究终点）在研究开始前已在ClinicalTrials.gov注册（NCT02308969）。在呈现恐惧面孔期间，相对于安慰剂，LSD的给药降低了左杏仁核和右内侧前额叶皮质的反应性（P<0.05，家族性错误）。值得注意的是，LSD诱导的杏仁核对恐惧刺激的反应与LSD诱导的主观药物效应之间存在显著负相关（P<0.05）。这些数据表明，急性给予LSD会调节介导情绪加工的脑区的参与度。
