Baird Amee, Umbach Heidi, Thompson William Forde
a Australian Research Council Centre of Excellence in Cognition and its Disorders and Psychology Department , Macquarie University , Sydney , Australia.
Neurocase. 2017 Feb;23(1):36-40. doi: 10.1080/13554794.2017.1287278. Epub 2017 Feb 21.
The hallmark symptom of Alzheimer's Dementia (AD) is impaired memory, but memory for familiar music can be preserved. We explored whether a non-musician with severe AD could learn a new song. A 91 year old woman (NC) with severe AD was taught an unfamiliar song. We assessed her delayed song recall (24 hours and 2 weeks), music cognition, two word recall (presented within a familiar song lyric, a famous proverb, or as a word stem completion task), and lyrics and proverb completion. NC's music cognition (pitch and rhythm perception, recognition of familiar music, completion of lyrics) was relatively preserved. She recalled 0/2 words presented in song lyrics or proverbs, but 2/2 word stems, suggesting intact implicit memory function. She could sing along to the newly learnt song on immediate and delayed recall (24 hours and 2 weeks later), and with intermittent prompting could sing it alone. This is the first detailed study of preserved ability to learn a new song in a non-musician with severe AD, and contributes to observations of relatively preserved musical abilities in people with dementia.
阿尔茨海默病性痴呆(AD)的标志性症状是记忆受损,但对熟悉音乐的记忆可能得以保留。我们探究了一名患有重度AD的非音乐家是否能够学会一首新歌。我们教一名91岁患有重度AD的女性(NC)一首陌生的歌曲。我们评估了她对歌曲的延迟回忆(24小时和2周后)、音乐认知、两个单词的回忆(在熟悉的歌曲歌词、一句著名谚语中呈现,或作为词干补全任务)以及歌词和谚语补全。NC的音乐认知(音高和节奏感知、对熟悉音乐的识别、歌词补全)相对保留。她在歌曲歌词或谚语中呈现的单词回忆为0/2,但词干回忆为2/2,这表明其内隐记忆功能完好。在即时回忆和延迟回忆(24小时和2周后)时,她能够跟着新学的歌曲一起唱,并且在间歇性提示下能够独自演唱。这是对一名患有重度AD的非音乐家学习新歌的保留能力进行的首次详细研究,有助于观察痴呆症患者相对保留的音乐能力。