Fu Yu, Chen Yanmei, Li Liane, Wang Yumei, Kong Xiangyang, Wang Jianhong
Medical Faculty, Kunming University of Science & Technology, Kunming, Yunnan 650500, PR China.
Medical Faculty, Kunming University of Science & Technology, Kunming, Yunnan 650500, PR China.
Int J Dev Neurosci. 2017 Aug;60:8-15. doi: 10.1016/j.ijdevneu.2017.03.010. Epub 2017 Apr 1.
The ambiguous effects of food restriction (FR) on cognition in rodents have been mostly explored in the aged brain by a variety of paradigms, in which either rewards or punishments are involved. This study aims to examine the effects of chronic and acute FR with varying intensities on spatial recognition memory in developing mice. We have used a Y-maze task that is based on the innate tendency of rodents to explore novel environments. In chronic FR, mice had 70-30% chow of control for seven weeks. In acute FR, mice were food restricted for 12-48h before the tests. We found that chronic FR had no effect on the preference of mice for novelty in the Y-maze, but severe FR (50-30% of control) caused impairment on spatial recognition memory. The impairment significantly correlated with the slow weight growth induced by FR. Acute FR also did not affect the novelty preference of mice, but either improved or impaired the memory retention. These data suggest chronic FR impairs Y-maze spatial recognition memory in developing mice depending on FR intensity and individual tolerability of the FR. Moreover, acute FR exerts diverse effects on the memory, either positive or negative. Our findings have revealed new insights on the effects of FR on spatial recognition memory in developing animals.
食物限制（FR）对啮齿动物认知的模糊影响大多是通过各种涉及奖励或惩罚的范式在老年大脑中进行探索的。本研究旨在研究不同强度的慢性和急性食物限制对发育中小鼠空间识别记忆的影响。我们使用了一种Y迷宫任务，该任务基于啮齿动物探索新环境的先天倾向。在慢性食物限制中，小鼠连续七周摄入对照食物量的70%-30%。在急性食物限制中，小鼠在测试前禁食12-48小时。我们发现慢性食物限制对小鼠在Y迷宫中对新奇事物的偏好没有影响，但严重的食物限制（对照的50%-30%）会导致空间识别记忆受损。这种损伤与食物限制引起的体重增长缓慢显著相关。急性食物限制也不影响小鼠对新奇事物的偏好，但会改善或损害记忆保持。这些数据表明，慢性食物限制会根据食物限制强度和个体对食物限制的耐受性损害发育中小鼠的Y迷宫空间识别记忆。此外，急性食物限制对记忆有不同的影响，既有积极的也有消极的。我们的研究结果揭示了食物限制对发育中动物空间识别记忆影响的新见解。
