Laboratorio de Psicología Experimental y Aplicada (PSEA), Instituto de Investigaciones Médicas (IDIM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires (UBA), Argentina.
Instituto de Investigación Médica M. y M. Ferreyra (INIMEC), CONICET Universidad Nacional de Córdoba (UNC), Argentina.
Neurosci Lett. 2021 Jul 13;757:135997. doi: 10.1016/j.neulet.2021.135997. Epub 2021 May 28.
Novelty seems to reduce the persistence of aversive memories and to modulate frustration responses, yet much less is known on how this treatment affects memories lacking hedonic or emotional content. The present study analyzed how a 5-min exposure to a novel open field modulated the expression of a spatial recognition memory. Experiment 1 indicated that male Wistar rats trained in a T-maze in which one goal arm is blocked exhibit, when tested 2 h later, preference for the novel arm. This recognition memory was impaired by the muscarinic cholinergic antagonist scopolamine. Postraining, but not pretraining, novelty exposure rescued the cognitive impairment induced by scopolamine (Experiment 2 and 3). Pretraining open field exposure alleviated the lack of memory expression, induced by imposing a 6 h delay between training and testing (Experiment 4). The study shows that a very brief exposure to novelty can improve expression of a spatial, recognition memory, a modulation that - in the case of the pretraining novelty exposure -- emerges even in spite of cholinergic blockade. The present results are consistent with research suggesting that novelty exposure can be an effective, non-pharmacological, treatment to modulate memory expression.
新颖性似乎可以降低厌恶记忆的持久性，并调节挫败感反应，但对于这种治疗方法如何影响缺乏享乐或情感内容的记忆，人们知之甚少。本研究分析了 5 分钟暴露于新开阔场如何调节空间识别记忆的表达。实验 1 表明，在 T 迷宫中接受训练的雄性 Wistar 大鼠，其中一个目标臂被阻断，当在 2 小时后进行测试时，它们会更喜欢新的臂。这种识别记忆会被毒蕈碱型胆碱能拮抗剂东莨菪碱损害。训练后但不是训练前的新颖性暴露可以挽救东莨菪碱引起的认知障碍（实验 2 和 3）。训练前的开阔场暴露缓解了由于在训练和测试之间施加 6 小时延迟而引起的记忆表达缺失（实验 4）。研究表明，非常短暂的新颖性暴露可以改善空间识别记忆的表达，这种调节——在训练前新颖性暴露的情况下——甚至在胆碱能阻断的情况下也会出现。目前的结果与研究一致，表明新颖性暴露可以作为一种有效的非药物治疗方法来调节记忆表达。
