Wright Ryan L, Conrad Cheryl D
Department of Psychology, Arizona State University, Tempe 85287-1104, USA.
Stress. 2005 Jun;8(2):151-4. doi: 10.1080/10253890500156663.
This experiment examined whether chronic stress disrupts novelty-seeking behavior under conditions that impair spatial memory. Rats were restrained for 6 h per day for 21 days, then tested in either a traditional spatial recognition Y-maze that requires extra-maze spatial cues to navigate or a version with salient intra-maze cues in addition to the extra-maze spatial cues. As previously shown, chronic restraint stress impaired performance on the spatial version of the Y-maze. However, chronically stressed rats performed well in the intra-maze cue version. The results indicate that the deficits in Y-maze performance following chronic stress are not attributed to neophobia, but likely reflect neurochemical and/or neurobiological changes underlying spatial memory ability.
本实验研究了在损害空间记忆的条件下，慢性应激是否会扰乱新奇寻求行为。大鼠每天被束缚6小时，持续21天，然后在传统的空间识别Y迷宫（需要迷宫外部空间线索来导航）或除迷宫外部空间线索外还具有显著迷宫内部线索的版本中进行测试。如先前所示，慢性束缚应激损害了Y迷宫空间版本的表现。然而，长期应激的大鼠在迷宫内部线索版本中表现良好。结果表明，慢性应激后Y迷宫表现的缺陷并非归因于新恐惧症，而是可能反映了空间记忆能力背后的神经化学和/或神经生物学变化。
