Ohtomo Ryo, Ishikawa Hidehiro, Kinoshita Keita, Chung Kelly K, Hamanaka Gen, Ohtomo Gaku, Takase Hajime, Wrann Christiane D, Katsuki Hiroshi, Iwata Atsushi, Lok Josephine, Lo Eng H, Arai Ken
Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Front Aging Neurosci. 2021 Dec 21;13:756537. doi: 10.3389/fnagi.2021.756537. eCollection 2021.
Clinical and basic research suggests that exercise is a safe behavioral intervention and is effective for improving cognitive function in cerebrovascular diseases, including subcortical ischemic vascular dementia (SIVD). However, most of the basic research uses young animals to assess the effects of exercise, although SIVD is an age-related disease. In this study, therefore, we used middle-aged mice to examine how treadmill exercise changes the cognitive function of SIVD mice. As a mouse model of SIVD, prolonged cerebral hypoperfusion was induced in 8-month-old male C57BL/6J mice by bilateral common carotid artery stenosis. A week later, the mice were randomly divided into two groups: a group that received 6-week treadmill exercise and a sedentary group for observation. After subjecting the mice to multiple behavioral tests (Y-maze, novel object recognition, and Morris water maze tests), the treadmill exercise training was shown to only be effective in ameliorating cognitive decline in the Y-maze test. We previously demonstrated that the same regimen of treadmill exercise was effective in young hypoperfused-SIVD mice for all three cognitive tests. Therefore, our study may indicate that treadmill exercise during cerebral hypoperfusion has only limited effects on cognitive function in aging populations.
临床和基础研究表明，运动是一种安全的行为干预方式，对改善包括皮质下缺血性血管性痴呆（SIVD）在内的脑血管疾病的认知功能有效。然而，尽管SIVD是一种与年龄相关的疾病，但大多数基础研究使用幼龄动物来评估运动的效果。因此，在本研究中，我们使用中年小鼠来研究跑步机运动如何改变SIVD小鼠的认知功能。作为SIVD的小鼠模型，通过双侧颈总动脉狭窄在8月龄雄性C57BL/6J小鼠中诱导长期脑灌注不足。一周后，将小鼠随机分为两组：一组接受6周的跑步机运动，另一组为久坐组进行观察。在对小鼠进行多项行为测试（Y迷宫、新物体识别和莫里斯水迷宫测试）后，发现跑步机运动训练仅在Y迷宫测试中有效改善认知衰退。我们之前证明，相同的跑步机运动方案对年轻的灌注不足型SIVD小鼠在所有三项认知测试中均有效。因此，我们的研究可能表明，脑灌注不足期间的跑步机运动对老年人群的认知功能影响有限。
